Open Collections

UBC Faculty Research and Publications

Neurologic Complications of Cancer Immunotherapy Alsalem, Aseel N.; Scarffe, Leslie A.; Briemberg, Hannah R.; Aaroe, Ashley E.; Harrison, Rebecca A.

Abstract

Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents.

Item Metadata

Title
Neurologic Complications of Cancer Immunotherapy
Creator
Alsalem, Aseel N.; Scarffe, Leslie A.; Briemberg, Hannah R.; Aaroe, Ashley E.; Harrison, Rebecca A.
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-06-19
Description
Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents.
Subject
immunotherapy; neurologic complications; checkpoint inhibition; CAR-T cells
Genre
Article
Type
Text
Language
eng
Date Available
2023-08-30
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0435649
URI
http://hdl.handle.net/2429/85700
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
Alsalem, A.N.; Scarffe, L.A.; Briemberg, H.R.; Aaroe, A.E.; Harrison, R.A. Neurologic Complications of Cancer Immunotherapy. Curr. Oncol. 2023, 30, 5876–5897.
Publisher DOI
10.3390/curroncol30060440
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

CC BY 4.0