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Defining the pediatric response to SARS-CoV-2 variants Ho, Reanne M.; Bowen, Asha C.; Blyth, Christopher C.; Imrie, Allison; Kollmann, Tobias R.; Stick, Stephen M.; Kicic, Anthony

Abstract

The global population has been severely affected by the coronavirus disease 2019 (COVID-19) pandemic, however, with older age identified as a risk factor, children have been underprioritized. This article discusses the factors contributing to the less severe response observed in children following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including, differing viral entry receptor expression and immune responses. It also discusses how emerging and future variants could present a higher risk to children, including those with underlying comorbidities, in developing severe disease. Furthermore, this perspective discusses the differential inflammatory markers between critical and non-critical cases, as well as discussing the types of variants that may be more pathogenic to children. Importantly, this article highlights where more research is urgently required, in order to protect the most vulnerable of our children.

Item Metadata

Title
Defining the pediatric response to SARS-CoV-2 variants
Creator
Ho, Reanne M.; Bowen, Asha C.; Blyth, Christopher C.; Imrie, Allison; Kollmann, Tobias R.; Stick, Stephen M.; Kicic, Anthony
Publisher
Frontiers Research Foundation
Date Issued
2023-05-25
Description
The global population has been severely affected by the coronavirus disease 2019 (COVID-19) pandemic, however, with older age identified as a risk factor, children have been underprioritized. This article discusses the factors contributing to the less severe response observed in children following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including, differing viral entry receptor expression and immune responses. It also discusses how emerging and future variants could present a higher risk to children, including those with underlying comorbidities, in developing severe disease. Furthermore, this perspective discusses the differential inflammatory markers between critical and non-critical cases, as well as discussing the types of variants that may be more pathogenic to children. Importantly, this article highlights where more research is urgently required, in order to protect the most vulnerable of our children.
Subject
COVID-19; SARS-CoV-2; Pediatric; Children; Emerging Variants; Molecular Biology; Cellular biology; Age-specific response
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2023-06-02
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International
DOI
10.14288/1.0433013
URI
http://hdl.handle.net/2429/84788
Affiliation
Medicine, Faculty of; Non UBC; Pediatrics, Department of
Citation
Ho RM, Bowen AC, Blyth CC, Imrie A, Kollmann TR, Stick SM and Kicic A (2023) Defining the pediatric response to SARS-CoV-2 variants. Front. Immunol. 14:1200456.
Publisher DOI
10.3389/fimmu.2023.1200456
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate
Copyright Holder
Authors
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International