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Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside McDonald, Paul C.; Chafe, Shawn C.; Supuran, Claudiu T.; Dedhar, Shoukat, 1952-

Abstract

Carbonic Anhydrase IX (CAIX) is a major metabolic effector of tumor hypoxia and regulates intra- and extracellular pH and acidosis. Significant advances have been made recently in the development of therapeutic targeting of CAIX. These approaches include antibody-based immunotherapy, as well as use of antibodies to deliver toxic and radioactive payloads. In addition, a large number of small molecule inhibitors which inhibit the enzymatic activity of CAIX have been described. In this commentary, we highlight the current status of strategies targeting CAIX in both the pre-clinical and clinical space, and discuss future perspectives that leverage inhibition of CAIX in combination with additional targeted therapies to enable effective, durable approaches for cancer therapy.

Item Metadata

Title
Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside
Creator
McDonald, Paul C.; Chafe, Shawn C.; Supuran, Claudiu T.; Dedhar, Shoukat, 1952-
Contributor
BC Cancer Research Centre; BC Cancer Research Centre. Integrative Oncology
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-07-06
Description
Carbonic Anhydrase IX (CAIX) is a major metabolic effector of tumor hypoxia and regulates intra- and extracellular pH and acidosis. Significant advances have been made recently in the development of therapeutic targeting of CAIX. These approaches include antibody-based immunotherapy, as well as use of antibodies to deliver toxic and radioactive payloads. In addition, a large number of small molecule inhibitors which inhibit the enzymatic activity of CAIX have been described. In this commentary, we highlight the current status of strategies targeting CAIX in both the pre-clinical and clinical space, and discuss future perspectives that leverage inhibition of CAIX in combination with additional targeted therapies to enable effective, durable approaches for cancer therapy.
Subject
hypoxia; Carbonic Anhydrase IX; immunotherapy; small molecule inhibitor; SLC-0111; acidosis; combination therapy; ferroptosis
Genre
Article
Type
Text
Language
eng
Date Available
2023-01-12
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0423042
URI
http://hdl.handle.net/2429/83635
Affiliation
Medicine, Faculty of; Non UBC; Biochemistry and Molecular Biology, Department of
Citation
Cancers 14 (14): 3297 (2022)
Publisher DOI
10.3390/cancers14143297
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0