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Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer Pauls, Mehrnoosh; Chia, Stephen; LeVasseur, Nathalie

Abstract

Triple-negative breast cancer (TNBC) has a worse prognosis and remains the most challenging breast cancer subtype to treat. This is largely related to the heterogeneity of this disease and the lack of reliable oncological targets. In this review, we discuss the current standard-of-care treatment options for metastatic TNBC, including recent advances with the use of immunotherapy, PARP inhibitors and antibody-drug conjugates. This review also explores new agents and novel combinations arising in the field for the treatment of advanced TNBC.

Item Metadata

Title
Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer
Creator
Pauls, Mehrnoosh; Chia, Stephen; LeVasseur, Nathalie
Contributor
BC Cancer Agency
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-07-07
Description
Triple-negative breast cancer (TNBC) has a worse prognosis and remains the most challenging breast cancer subtype to treat. This is largely related to the heterogeneity of this disease and the lack of reliable oncological targets. In this review, we discuss the current standard-of-care treatment options for metastatic TNBC, including recent advances with the use of immunotherapy, PARP inhibitors and antibody-drug conjugates. This review also explores new agents and novel combinations arising in the field for the treatment of advanced TNBC.
Subject
metastatic TNBC; immunotherapy; PARP inhibitor; antibody-drug conjugate (ADC); PI3K/AKT/mTOR
Genre
Article
Type
Text
Language
eng
Date Available
2022-12-06
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0422400
URI
http://hdl.handle.net/2429/83369
Affiliation
Other UBC
Citation
Current Oncology 29 (7): 4748-4767 (2022)
Publisher DOI
10.3390/curroncol29070377
Peer Review Status
Reviewed
Scholarly Level
Researcher; Other
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Rights

CC BY 4.0