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Association between Cumulative Joint Loading from Occupational Activities and Knee Osteoarthritis Ezzat, Allison M.; Cibere, Jolanda, 1962-; Koehoorn, Mieke, 1966-; Li, Linda C.

Abstract

Objective: To determine the associations between cumulative occupational physical load (COPL) and three definitions of knee osteoarthritis. Methods: Cross-sectional analyses were performed from two population-based cohorts (n=327). Eligible symptomatic participants were those with pain, aching, or discomfort in or around the knee on most days of a month at any time in the past and any pain in the past 12 months. Asymptomatic participants responded “no” to both knee pain questions. Self-reported COPL was calculated over each participant’s lifetime, and then categorized into quarters (i.e., QCOPL). Radiographic osteoarthritis (ROA) and symptomatic osteoarthritis (SOA) were defined by Kellgren Lawrence grade >2, with SOA also including pain. Magnetic resonance imaging osteoarthritis (MRIOA) was defined using criteria by Hunter and associates. Logistic regression, adjusted with population weights, examined the associations between QCOPL and ROA, SOA, and MRI-OA, respectively, after controlling for covariates and two-way interactions. Results: Participants were on average 58.5 (SD=11.0) years old with a BMI of 26.3 (SD=4.7). Of those, 109(33.3%) had ROA, 102(31.2%) had SOA and 131(40.1%) had MRI-OA. Compared with QCOPL-1, increased odds of ROA were found for QCOPL-4 (Odds ratio (OR)=3.15; 95% Confidence Interval (CI)=1.02, 9.70) and QCOPL-3 (OR=4.19; 95% CI=1.55, 11.34). Statistically significant relationships were found in SOA (QCOPL-4: OR=8.16; 95% CI=1.89, 35.27; QCOPL3: OR=5.73; 95% CI=1.36, 24.12) and MRI-OA (QCOPL-4: OR=9.54; 95% CI=2.65, 34.27; QCOPL-3: OR=9.04; 95% CI=2.65, 30.88; QCOPL-2: OR=7.18; 95% CI=2.17, 23.70.) Conclusion: Occupational activity is associated with knee OA with dose-response relationships observed in SOA and MRI-OA.

Item Metadata

Title
Association between Cumulative Joint Loading from Occupational Activities and Knee Osteoarthritis
Creator
Ezzat, Allison M.; Cibere, Jolanda, 1962-; Koehoorn, Mieke, 1966-; Li, Linda C.
Contributor
Arthritis Research Canada
Date Issued
2013-10
Description
Objective: To determine the associations between cumulative occupational physical load (COPL) and three definitions of knee osteoarthritis. Methods: Cross-sectional analyses were performed from two population-based cohorts (n=327). Eligible symptomatic participants were those with pain, aching, or discomfort in or around the knee on most days of a month at any time in the past and any pain in the past 12 months. Asymptomatic participants responded “no” to both knee pain questions. Self-reported COPL was calculated over each participant’s lifetime, and then categorized into quarters (i.e., QCOPL). Radiographic osteoarthritis (ROA) and symptomatic osteoarthritis (SOA) were defined by Kellgren Lawrence grade >2, with SOA also including pain. Magnetic resonance imaging osteoarthritis (MRIOA) was defined using criteria by Hunter and associates. Logistic regression, adjusted with population weights, examined the associations between QCOPL and ROA, SOA, and MRI-OA, respectively, after controlling for covariates and two-way interactions. Results: Participants were on average 58.5 (SD=11.0) years old with a BMI of 26.3 (SD=4.7). Of those, 109(33.3%) had ROA, 102(31.2%) had SOA and 131(40.1%) had MRI-OA. Compared with QCOPL-1, increased odds of ROA were found for QCOPL-4 (Odds ratio (OR)=3.15; 95% Confidence Interval (CI)=1.02, 9.70) and QCOPL-3 (OR=4.19; 95% CI=1.55, 11.34). Statistically significant relationships were found in SOA (QCOPL-4: OR=8.16; 95% CI=1.89, 35.27; QCOPL3: OR=5.73; 95% CI=1.36, 24.12) and MRI-OA (QCOPL-4: OR=9.54; 95% CI=2.65, 34.27; QCOPL-3: OR=9.04; 95% CI=2.65, 30.88; QCOPL-2: OR=7.18; 95% CI=2.17, 23.70.) Conclusion: Occupational activity is associated with knee OA with dose-response relationships observed in SOA and MRI-OA.
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2022-10-21
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0421399
URI
http://hdl.handle.net/2429/82966
Affiliation
Medicine, Faculty of; Medicine, Department of; Physical Therapy, Department of; Population and Public Health (SPPH), School of
Citation
Ezzat A, Cibere J, Koehoorn M, Li LC. Association between cumulated joint loading from occupational activities in knee osteoarthritis. Arthritis Care & Research. 65(10):1634-1642, 2013
Publisher DOI
10.1002/acr.22033
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International