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Willingness to Self-Collect a Sample for HPV-Based Cervical Cancer Screening in a Well-Screened Cohort: HPV FOCAL Survey Results Lesack, Anne; Smith, Laurie W.; Racey, C. Sarai; Gondara, Lovedeep; Krajden, Mel; Lee, Marette; Martin, Ruth Elwood, 1954-; Stuart, Gavin; Peacock, Stuart; Franco, Eduardo L.; Van Niekerk, Dirk; Ogilvie, Gina

Abstract

Self-collection may provide an opportunity for innovation within population-based human papillomavirus (HPV) cervical cancer screening programs by providing an alternative form of engagement for all individuals. The primary objective was to determine willingness to self-collect a vaginal sample for primary HPV screening and factors that impact willingness in individuals who participated in the Human Papillomavirus For Cervical Cancer (HPV FOCAL) screening trial, a large randomized controlled cervical screening trial. A cross-sectional online survey was distributed between 2017 and 2018 to 13,176 eligible participants exiting the FOCAL trial. Bivariate and multivariable logistic regression assessed factors that influence willingness to self-collect on 4945 respondents. Overall, 52.1% of respondents indicated willingness to self-collect an HPV sample. In multivariable analysis, the odds of willingness to self-collect were significantly higher in participants who agreed that screening with an HPV test instead of a Pap test was acceptable to them (odds ratio (OR): 1.45 (95% confidence interval (CI): 1.15, 1.82), those who indicated that collecting their own HPV sample was acceptable to them (p < 0.001), and those with higher educational ascertainment (OR: 1.31, 95% CI: 1.12, 1.54). The findings offer insight into the intentions to self-collect in those already engaged in screening, and can inform cervical cancer screening programs interested in offering alternative approaches to HPV-based screening.

Item Metadata

Title
Willingness to Self-Collect a Sample for HPV-Based Cervical Cancer Screening in a Well-Screened Cohort: HPV FOCAL Survey Results
Creator
Lesack, Anne; Smith, Laurie W.; Racey, C. Sarai; Gondara, Lovedeep; Krajden, Mel; Lee, Marette; Martin, Ruth Elwood, 1954-; Stuart, Gavin; Peacock, Stuart; Franco, Eduardo L.; Van Niekerk, Dirk; Ogilvie, Gina
Contributor
BC Cancer Research Centre; Women's Health Research Institute (British Columbia); Women's Hospital (Vancouver, B.C.); BC Centre for Disease Control; Provincial Health Services Authority (B.C.)
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-05-26
Description
Self-collection may provide an opportunity for innovation within population-based human papillomavirus (HPV) cervical cancer screening programs by providing an alternative form of engagement for all individuals. The primary objective was to determine willingness to self-collect a vaginal sample for primary HPV screening and factors that impact willingness in individuals who participated in the Human Papillomavirus For Cervical Cancer (HPV FOCAL) screening trial, a large randomized controlled cervical screening trial. A cross-sectional online survey was distributed between 2017 and 2018 to 13,176 eligible participants exiting the FOCAL trial. Bivariate and multivariable logistic regression assessed factors that influence willingness to self-collect on 4945 respondents. Overall, 52.1% of respondents indicated willingness to self-collect an HPV sample. In multivariable analysis, the odds of willingness to self-collect were significantly higher in participants who agreed that screening with an HPV test instead of a Pap test was acceptable to them (odds ratio (OR): 1.45 (95% confidence interval (CI): 1.15, 1.82), those who indicated that collecting their own HPV sample was acceptable to them (p < 0.001), and those with higher educational ascertainment (OR: 1.31, 95% CI: 1.12, 1.54). The findings offer insight into the intentions to self-collect in those already engaged in screening, and can inform cervical cancer screening programs interested in offering alternative approaches to HPV-based screening.
Subject
human papillomavirus; HPV; HPV self-sampling; HPV testing for cervix screening; attitudes and acceptance HPV self-sampling
Genre
Article
Type
Text
Language
eng
Date Available
2022-09-13
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0419374
URI
http://hdl.handle.net/2429/82696
Affiliation
Medicine, Faculty of; Non UBC
Citation
Current Oncology 29 (6): 3860-3869 (2022)
Publisher DOI
10.3390/curroncol29060308
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0