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Biliary Atresia in 2021: Epidemiology, Screening and Public Policy Schreiber, Richard A.; Harpavat, Sanjiv; Hulscher, Jan B. F.; Wildhaber, Barbara E.

Abstract

Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Timely intervention with a Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed disease recognition, late patient referral, and untimely surgery remains a worldwide problem. This article will focus on biliary atresia from a global public health perspective, including disease epidemiology, current national screening programs, and their impact on outcome, as well as new and novel BA screening initiatives. Policy challenges for the implementation of BA screening programs will also be discussed, highlighting examples from the North American, European, and Asian experience.

Item Metadata

Title
Biliary Atresia in 2021: Epidemiology, Screening and Public Policy
Creator
Schreiber, Richard A.; Harpavat, Sanjiv; Hulscher, Jan B. F.; Wildhaber, Barbara E.
Contributor
University of British Columbia. Gastroenterology, Hepatology & Nutrition
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-02-14
Description
Biliary atresia (BA) is a rare newborn liver disease with significant morbidity and mortality, especially if not recognized and treated early in life. It is the most common cause of liver-related death in children and the leading indication for liver transplantation in the pediatric population. Timely intervention with a Kasai portoenterostomy (KPE) can significantly improve prognosis. Delayed disease recognition, late patient referral, and untimely surgery remains a worldwide problem. This article will focus on biliary atresia from a global public health perspective, including disease epidemiology, current national screening programs, and their impact on outcome, as well as new and novel BA screening initiatives. Policy challenges for the implementation of BA screening programs will also be discussed, highlighting examples from the North American, European, and Asian experience.
Subject
biliary atresia; pediatric liver disease; newborn screening; public health; epidemiology
Genre
Article
Type
Text
Language
eng
Date Available
2022-03-24
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0407312
URI
http://hdl.handle.net/2429/81022
Affiliation
Medicine, Faculty of; Non UBC; Gastroenterology, Division of; Medicine, Department of; Pediatrics, Department of
Citation
Journal of Clinical Medicine 11 (4): 999 (2022)
Publisher DOI
10.3390/jcm11040999
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Other
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0