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The Arginine Catabolism-Derived Amino Acid l-ornithine Is a Chemoattractant for Pseudomonas aeruginosa Dhodary, Basanta; Sampedro, Inmaculada; Behroozian, Shekooh; Borza, Victor; Her, Stephanie; Hill, Jane E.

Abstract

Pseudomonas aeruginosa is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, l-ornithine, a non-proteinogenic amino acid, becomes more abundant. P. aeruginosa is chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response of P. aeruginosa towards l-ornithine. Our results show that l-ornithine serves as a chemoattractant for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved in P. aeruginosa PAO1 are PctA and PctB. It seems likely that P. aeruginosa’s chemotactic response to l-ornithine might be a common feature and thus could potentially contribute to pathogenesis processes during colonization and infection scenarios.

Item Metadata

Title
The Arginine Catabolism-Derived Amino Acid l-ornithine Is a Chemoattractant for Pseudomonas aeruginosa
Creator
Dhodary, Basanta; Sampedro, Inmaculada; Behroozian, Shekooh; Borza, Victor; Her, Stephanie; Hill, Jane E.
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-01-24
Description
Pseudomonas aeruginosa is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, l-ornithine, a non-proteinogenic amino acid, becomes more abundant. P. aeruginosa is chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response of P. aeruginosa towards l-ornithine. Our results show that l-ornithine serves as a chemoattractant for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved in P. aeruginosa PAO1 are PctA and PctB. It seems likely that P. aeruginosa’s chemotactic response to l-ornithine might be a common feature and thus could potentially contribute to pathogenesis processes during colonization and infection scenarios.
Subject
chemotaxis; l-ornithine; Pseudomonas aeruginosa; chemoreceptor
Genre
Article
Type
Text
Language
eng
Date Available
2022-03-24
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0407303
URI
http://hdl.handle.net/2429/81014
Affiliation
Applied Science, Faculty of; Non UBC; Biomedical Engineering, School of
Citation
Microorganisms 10 (2): 264 (2022)
Publisher DOI
10.3390/microorganisms10020264
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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CC BY 4.0