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Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action Drayton, Matthew; Deisinger, Julia P.; Ludwig, Kevin C.; Raheem, Nigare; Müller, Anna; Schneider, Tanja; Straus, Suzana

Abstract

The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which include direct killing as well as immunomodulatory properties (e.g., anti-inflammatory activity). HDPs may hence provide a more robust treatment of bacterial infections. In this review, the advent of and the mechanisms that lead to antibiotic resistance will be described. HDP mechanisms of antibacterial and immunomodulatory action will be presented, with specific examples of how the HDP aurein 2.2 and a few of its derivatives, namely peptide 73 and cG4L73, function. Finally, resistance that may arise from a broader use of HDPs in a clinical setting and methods to improve biocompatibility will be briefly discussed.

Item Metadata

Title
Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action
Creator
Drayton, Matthew; Deisinger, Julia P.; Ludwig, Kevin C.; Raheem, Nigare; Müller, Anna; Schneider, Tanja; Straus, Suzana
Contributor
University of British Columbia. Centre for Blood Research
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2021-10-16
Description
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which include direct killing as well as immunomodulatory properties (e.g., anti-inflammatory activity). HDPs may hence provide a more robust treatment of bacterial infections. In this review, the advent of and the mechanisms that lead to antibiotic resistance will be described. HDP mechanisms of antibacterial and immunomodulatory action will be presented, with specific examples of how the HDP aurein 2.2 and a few of its derivatives, namely peptide 73 and cG4L73, function. Finally, resistance that may arise from a broader use of HDPs in a clinical setting and methods to improve biocompatibility will be briefly discussed.
Subject
host defense peptides (HDPs); antimicrobial peptides (AMPs); antibacterial; immune modulation; resistance; biocompatibility
Genre
Article
Type
Text
Language
eng
Date Available
2021-11-18
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0403715
URI
http://hdl.handle.net/2429/80220
Affiliation
Science, Faculty of; Non UBC; Chemistry, Department of
Citation
International Journal of Molecular Sciences 22 (20): 11172 (2021)
Publisher DOI
10.3390/ijms222011172
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0