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COPD and the risk of poor outcomes in COVID-19 : A systematic review and meta-analysis Gerayeli, Firoozeh; Milne, Stephen; Cheung, Chung; Li, Xuan; Yang, Cheng Wei Tony; Tam, Anthony; Choi, Lauren H.; Bae, Annie; Sin, Don
Abstract
Background: Patients with chronic obstructive pulmonary disease (COPD) are highly susceptible from respiratory exacerbations from viral respiratory tract infections. However, it is unclear whether they are at increased risk of COVID-19 pneumonia or COVID-19-related mortality. We aimed to determine whether COPD is a risk factor for adverse COVID-19 outcomes including hospitalization, severe COVID-19, or death. Methods: Following the PRISMA guidelines, we performed a systematic review of COVID-19 clinical studies published between November 1st, 2019 and January 28th, 2021 (PROSPERO ID: CRD42020191491). We included studies that quantified the number of COPD patients, and reported at least one of the following outcomes stratified by COPD status: hospitalization; severe COVID-19; ICU admission; mechanical ventilation; acute respiratory distress syndrome; or mortality. We meta-analyzed the results of individual studies to determine the odds ratio (OR) of these outcomes in patients with COPD compared to those without COPD. Findings: Fifty-nine studies met the inclusion criteria, and underwent data extraction. Most studies were retrospective cohort studies/case series of hospitalized patients. Only four studies examined the effects of COPD on COVID-19 outcomes as their primary endpoint. In aggregate, COPD was associated with increased odds of hospitalization (OR 4.23, 95% confidence interval [CI] 3.65 4.90), ICU admission (OR 1.35, 95% CI 1.02 1.78), and mortality (OR 2.47, 95% CI 2.18 2.79). Interpretation: Having a clinical diagnosis of COPD significantly increases the odds of poor clinical outcomes in patients with COVID-19. COPD patients should thus be considered a high-risk group, and targeted for preventative measures and aggressive treatment for COVID-19 including vaccination.
Item Metadata
Title |
COPD and the risk of poor outcomes in COVID-19 : A systematic review and meta-analysis
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Creator | |
Contributor | |
Publisher |
Elsevier
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Date Issued |
2021-03-18
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Description |
Background: Patients with chronic obstructive pulmonary disease (COPD) are highly susceptible from respiratory exacerbations from viral respiratory tract infections. However, it is unclear whether they are at
increased risk of COVID-19 pneumonia or COVID-19-related mortality. We aimed to determine whether
COPD is a risk factor for adverse COVID-19 outcomes including hospitalization, severe COVID-19, or death.
Methods: Following the PRISMA guidelines, we performed a systematic review of COVID-19 clinical studies
published between November 1st, 2019 and January 28th, 2021 (PROSPERO ID: CRD42020191491). We
included studies that quantified the number of COPD patients, and reported at least one of the following outcomes stratified by COPD status: hospitalization; severe COVID-19; ICU admission; mechanical ventilation;
acute respiratory distress syndrome; or mortality. We meta-analyzed the results of individual studies to
determine the odds ratio (OR) of these outcomes in patients with COPD compared to those without COPD.
Findings: Fifty-nine studies met the inclusion criteria, and underwent data extraction. Most studies were retrospective cohort studies/case series of hospitalized patients. Only four studies examined the effects of COPD
on COVID-19 outcomes as their primary endpoint. In aggregate, COPD was associated with increased odds of
hospitalization (OR 4.23, 95% confidence interval [CI] 3.65 4.90), ICU admission (OR 1.35, 95% CI 1.02 1.78),
and mortality (OR 2.47, 95% CI 2.18 2.79).
Interpretation: Having a clinical diagnosis of COPD significantly increases the odds of poor clinical outcomes
in patients with COVID-19. COPD patients should thus be considered a high-risk group, and targeted for preventative measures and aggressive treatment for COVID-19 including vaccination.
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Subject | |
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Type | |
Language |
eng
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Date Available |
2021-10-28
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0402659
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URI | |
Affiliation | |
Citation |
Gerayeli, F. V., Milne, S., Cheung, C., Li, X., Yang, C. W. T., Tam, A., Choi, L. H., Bae, A., & Sin, D. D. (2021). COPD and the risk of poor outcomes in COVID-19: A systematic review and meta-analysis. Eclinicalmedicine, 33, 100789-100789.
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Publisher DOI |
10.1016/j.eclinm.2021.100789
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty; Researcher; Postdoctoral; Graduate
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Copyright Holder |
Authors
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DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International