UBC Faculty Research and Publications

Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection : A Case Report Sherwood, Karen; Nicholl, David; Fenninger, Franz; Wu, Vivian; Wong, Paaksum; Benedicto, Vince; Cina, Davide; Wang, Meng; Pobran, Taylor; De Marco, Mari L; Jassem, Agatha; Sekirov, Inna; Morshed, Muhammad; Bardi, Mohammad; Sekhon, Mypinder; Keown, Paul A.; Kadatz, Matthew; Lan, James H.

Abstract

To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.

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