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Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy Evangelidis, Nicole; Sautenet, Benedicte; Madero, Magdalena; Tong, Allison; Ashuntantang, Gloria; Sanabria, Laura C.; de Boer, Ian H.; Fung, Samuel; Gallego, Daniel; Levey, Andrew S.; et al.

Abstract

Background Globally, over 1.2 million people die from chronic kidney disease (CKD) every year. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacement therapy. The burden of symptoms and impaired quality of life in CKD may be compounded by comorbidities and treatment side effects. However, patient-important outcomes remain inconsistently and infrequently reported in trials in patients with CKD, which can limit evidence-informed decision-making. The Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD) aims to establish a consensus-based core outcome set for trials in patients with CKD not yet requiring kidney replacement therapy to ensure outcomes of relevance to patients, caregivers and health professionals are consistently reported in trials. Methods SONG-CKD involves four phases: a systematic review to identify outcomes (domains and measures) that have been reported in randomised controlled trials involving adults with CKD who do not require kidney replacement therapy; stakeholder key informant interviews with health professionals involved in the care of adults with CKD to ascertain their views on establishing core outcomes in CKD; an international two-round online Delphi survey with patients, caregivers, clinicians, researchers, policy makers and industry representatives to obtain consensus on critically important outcome domains; and stakeholder consensus workshops to review and finalise the set of core outcome domains for trials in CKD. Discussion Establishing a core outcome set to be reported in trials in patients with CKD will enhance the relevance, transparency and impact of research to improve the lives of people with CKD. Trial registration Not applicable. This study is registered with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/Studies/Details/1653 .

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Title
Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy
Creator
Evangelidis, Nicole; Sautenet, Benedicte; Madero, Magdalena; Tong, Allison; Ashuntantang, Gloria; Sanabria, Laura C.; de Boer, Ian H.; Fung, Samuel; Gallego, Daniel; Levey, Andrew S.; Levin, A. (Adeera); Lorca, Eduardo; Okpechi, Ikechi G.; Rossignol, Patrick; Sola, Laura; Usherwood, Tim; Wheeler, David C.; Cho, Yeoungjee; Howell, Martin; Guha, Chandana; Scholes-Robertson, Nicole; Widders, Katherine; Gonzalez, Andrea M.; Teixeira-Pinto, Armando; Viecelli, Andrea K.; Bernier-Jean, Amelie; Anumudu, Samaya; Dunn, Louese; Wilkie, Martin; Craig, Jonathan C.
Publisher
BioMed Central
Date Issued
2021-09-09
Description
Background Globally, over 1.2 million people die from chronic kidney disease (CKD) every year. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacement therapy. The burden of symptoms and impaired quality of life in CKD may be compounded by comorbidities and treatment side effects. However, patient-important outcomes remain inconsistently and infrequently reported in trials in patients with CKD, which can limit evidence-informed decision-making. The Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD) aims to establish a consensus-based core outcome set for trials in patients with CKD not yet requiring kidney replacement therapy to ensure outcomes of relevance to patients, caregivers and health professionals are consistently reported in trials. Methods SONG-CKD involves four phases: a systematic review to identify outcomes (domains and measures) that have been reported in randomised controlled trials involving adults with CKD who do not require kidney replacement therapy; stakeholder key informant interviews with health professionals involved in the care of adults with CKD to ascertain their views on establishing core outcomes in CKD; an international two-round online Delphi survey with patients, caregivers, clinicians, researchers, policy makers and industry representatives to obtain consensus on critically important outcome domains; and stakeholder consensus workshops to review and finalise the set of core outcome domains for trials in CKD. Discussion Establishing a core outcome set to be reported in trials in patients with CKD will enhance the relevance, transparency and impact of research to improve the lives of people with CKD. Trial registration Not applicable. This study is registered with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/Studies/Details/1653 .
Subject
Core outcome set; Outcomes research; Patient-centred outcomes; Clinical trials; Chronic kidney disease
Genre
Article
Type
Text
Language
eng
Date Available
2021-10-06
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0402452
URI
http://hdl.handle.net/2429/79899
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of; Neurology, Division of
Citation
Trials. 2021 Sep 09;22(1):612
Publisher DOI
10.1186/s13063-021-05574-1
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)