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Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity Mousavi, Seyyed Mojtaba; Hashemi, Seyyed Alireza; Mazraedoost, Sargol; Yousefi, Khadije; Gholami, Ahmad; Behbudi, Gity; Ramakrishna, Seeram; Omidifar, Navid; Alizadeh, Ali; Chiang, Wei-Hung

Abstract

Multifunctional gold nanorods (GNR) have drawn growing interest in biomedical fields because of their excellent biocompatibility, ease of alteration, and special optical properties. The great advantage of using GNR in medicine is their application to Photothermal therapy (PPTT), which is possible thanks to their ability to turn luminous energy into heat to cause cellular hyperthermia. For this purpose, the relevant articles between 1988 and 2020 were searched in databases such as John Wiley, Free paper, Scopus, Science Direct, and Springer to obtain the latest findings on multifunctional gold nanorods for therapeutic applications and pharmaceutical delivery. In this article, we review recent progress in diagnostic and therapeutic applications of multifunctional GNR, highlighting new information about their toxicity to various cellular categories, oxidative stress, cellular longevity, and their metabolic effects, such as the effect on the energy cycles and genetic structures. The methods for the synthesis and functionalization of GNR were surveyed. This review includes new information about GNR toxicity to various cellular categories and their metabolic effects.

Item Metadata

Title
Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity
Creator
Mousavi, Seyyed Mojtaba; Hashemi, Seyyed Alireza; Mazraedoost, Sargol; Yousefi, Khadije; Gholami, Ahmad; Behbudi, Gity; Ramakrishna, Seeram; Omidifar, Navid; Alizadeh, Ali; Chiang, Wei-Hung
Contributor
University of British Columbia. Nanomaterials and Polymer Nanocomposites Laboratory
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2021-07-20
Description
Multifunctional gold nanorods (GNR) have drawn growing interest in biomedical fields because of their excellent biocompatibility, ease of alteration, and special optical properties. The great advantage of using GNR in medicine is their application to Photothermal therapy (PPTT), which is possible thanks to their ability to turn luminous energy into heat to cause cellular hyperthermia. For this purpose, the relevant articles between 1988 and 2020 were searched in databases such as John Wiley, Free paper, Scopus, Science Direct, and Springer to obtain the latest findings on multifunctional gold nanorods for therapeutic applications and pharmaceutical delivery. In this article, we review recent progress in diagnostic and therapeutic applications of multifunctional GNR, highlighting new information about their toxicity to various cellular categories, oxidative stress, cellular longevity, and their metabolic effects, such as the effect on the energy cycles and genetic structures. The methods for the synthesis and functionalization of GNR were surveyed. This review includes new information about GNR toxicity to various cellular categories and their metabolic effects.
Subject
multifunctional gold nanorods; therapeutic applications; cellular metabolic responses; oxidative stress; cellular longevity
Genre
Article
Type
Text
Language
eng
Date Available
2021-08-06
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0401239
URI
http://hdl.handle.net/2429/79211
Affiliation
Applied Science, Faculty of; Non UBC; Engineering, School of (Okanagan)
Citation
Nanomaterials 11 (7): 1868 (2021)
Publisher DOI
10.3390/nano11071868
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0