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Airway-On-A-Chip: Designs and Applications for Lung Repair and Disease Bennet, Tanya J.; Randhawa, Avineet; Hua, Jessica; Cheung, Karen C.

Abstract

The lungs are affected by illnesses including asthma, chronic obstructive pulmonary disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models for respiratory conditions will be essential for new drug development. The composition and structure of the lung extracellular matrix (ECM) plays a major role in the function of the lung tissue and cells. Lung-on-chip models have been developed to address some of the limitations of current two-dimensional in vitro models. In this review, we describe various ECM substitutes utilized for modeling the respiratory system. We explore the application of lung-on-chip models to the study of cigarette smoke and electronic cigarette vapor. We discuss the challenges and opportunities related to model characterization with an emphasis on in situ characterization methods, both established and emerging. We discuss how further advancements in the field, through the incorporation of interstitial cells and ECM, have the potential to provide an effective tool for interrogating lung biology and disease, especially the mechanisms that involve the interstitial elements.

Item Metadata

Title
Airway-On-A-Chip: Designs and Applications for Lung Repair and Disease
Creator
Bennet, Tanya J.; Randhawa, Avineet; Hua, Jessica; Cheung, Karen C.
Contributor
University of British Columbia. Centre for Blood Research
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2021-06-26
Description
The lungs are affected by illnesses including asthma, chronic obstructive pulmonary disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models for respiratory conditions will be essential for new drug development. The composition and structure of the lung extracellular matrix (ECM) plays a major role in the function of the lung tissue and cells. Lung-on-chip models have been developed to address some of the limitations of current two-dimensional in vitro models. In this review, we describe various ECM substitutes utilized for modeling the respiratory system. We explore the application of lung-on-chip models to the study of cigarette smoke and electronic cigarette vapor. We discuss the challenges and opportunities related to model characterization with an emphasis on in situ characterization methods, both established and emerging. We discuss how further advancements in the field, through the incorporation of interstitial cells and ECM, have the potential to provide an effective tool for interrogating lung biology and disease, especially the mechanisms that involve the interstitial elements.
Subject
airway-on-a-chip; microfluidics; extracellular matrix; epithelial cells; endothelial cells; fibroblasts; remodeling; exposures; cigarette smoke; electronic cigarettes; analysis methods; bio-imaging
Genre
Article
Type
Text
Language
eng
Date Available
2021-07-26
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0400909
URI
http://hdl.handle.net/2429/79094
Affiliation
Applied Science, Faculty of; Medicine, Faculty of; Biomedical Engineering, School of; Materials Engineering, Department of
Citation
Cells 10 (7): 1602 (2021)
Publisher DOI
10.3390/cells10071602
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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CC BY 4.0