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Experimental and natural evidence of SARS-CoV- 2-infection-induced activation of type I interferon responses Banerjee, Arinjay; El-Sayes, Nader; Budylowski, Patrick; Jacob, Rajesh Abraham; Richard, Daniel; Maan, Hassaan; Aguiar, Jennifer A.; Demian, Wael L.; Baid, Kaushal; D'Agostino, Michael R.; Ang, Jann; Murdza, Tetyana; Tremblay, Benjamin J.-M.; Afkhami, Sam; Karimzadeh, Mehran; Irving, Aaron T.; Yip, Lily; Ostrowski, Mario; Hirota, Jeremy; Kozak, Robert; Capellini, Terence D.; Miller, Matthew S.; Wang, Bo; Mubareka, Samira; McGeer, Allison J.; McArthur, Andrew G.; Doxey, Andrew C.; Mossman, Karen
Abstract
Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associated withmanifestation of COVID-19 severity. In spite of progress in understanding how SARS-CoV-2 activates antiviral responses, mechanistic studies into wild-type SARS-CoV-2-mediated induction and inhibition of human type I IFN responses are scarce. Here we demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and inmoderate cases of COVID-19. In vitro stimulation of type I IFN expression and signaling in human airway epithelial cells is associated with activation of canonical transcriptions factors, and SARS-CoV-2 is unable to inhibit exogenous induction of these responses. Furthermore, we show that physiological levels of IFNa detected in patients with moderate COVID-19 is sufficient to suppress SARS-CoV-2 replication in human airway cells.
Item Metadata
| Title |
Experimental and natural evidence of SARS-CoV- 2-infection-induced activation of type I interferon responses
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| Creator |
Banerjee, Arinjay; El-Sayes, Nader; Budylowski, Patrick; Jacob, Rajesh Abraham; Richard, Daniel; Maan, Hassaan; Aguiar, Jennifer A.; Demian, Wael L.; Baid, Kaushal; D'Agostino, Michael R.; Ang, Jann; Murdza, Tetyana; Tremblay, Benjamin J.-M.; Afkhami, Sam; Karimzadeh, Mehran; Irving, Aaron T.; Yip, Lily; Ostrowski, Mario; Hirota, Jeremy; Kozak, Robert; Capellini, Terence D.; Miller, Matthew S.; Wang, Bo; Mubareka, Samira; McGeer, Allison J.; McArthur, Andrew G.; Doxey, Andrew C.; Mossman, Karen
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| Publisher |
Cell Press
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| Date Issued |
2021-05-21
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| Description |
Type I interferons (IFNs) are our first line of defense against virus infection.
Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit
IFN responses. Emerging data also suggest that timing and extent of IFN production
is associated withmanifestation of COVID-19 severity. In spite of progress in
understanding how SARS-CoV-2 activates antiviral responses, mechanistic
studies into wild-type SARS-CoV-2-mediated induction and inhibition of human
type I IFN responses are scarce. Here we demonstrate that SARS-CoV-2 infection
induces a type I IFN response in vitro and inmoderate cases of COVID-19. In vitro
stimulation of type I IFN expression and signaling in human airway epithelial cells
is associated with activation of canonical transcriptions factors, and SARS-CoV-2
is unable to inhibit exogenous induction of these responses. Furthermore, we
show that physiological levels of IFNa detected in patients with moderate
COVID-19 is sufficient to suppress SARS-CoV-2 replication in human airway cells.
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| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2021-06-25
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0398535
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| URI | |
| Affiliation | |
| Citation |
Banerjee, A., El-Sayes, N., Budylowski, P., Jacob, R. A., Richard, D., Maan, H., Aguiar, J. A., Demian, W. L., Baid, K., D'Agostino, M. R., Ang, J. C., Murdza, T., Tremblay, B. J. -., Afkhami, S., Karimzadeh, M., Irving, A. T., Yip, L., Ostrowski, M., Hirota, J. A., . . . Mossman, K. (2021). Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses. Iscience, 24(5).
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| Publisher DOI |
10.1016/j.isci.2021.102477
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher; Postdoctoral; Graduate
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| Copyright Holder |
Authors
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International