- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Faculty Research and Publications /
- The Association of Inflammatory Cytokines in the Pulmonary...
Open Collections
UBC Faculty Research and Publications
The Association of Inflammatory Cytokines in the Pulmonary Pathophysiology of Respiratory Failure in Critically Ill Patients With Coronavirus Disease 2019 Stukas, Sophie; Hoiland, Ryan; Cooper, Jennifer; Thiara, Sonny; Griesdale, Donald E.; Thomas, Adam D.; Orde, Matthew M.; English, John C.; Chen, Luke Y. C.; Foster, Denise; Mitra, Anish; Romano, Kali; Sweet, David; Ronco, Juan J.; Kanji, Hussein; Chen, Yu-Wei R.; Wong, Sophia; Wellington, Cheryl L.; Sekhon, Mypinder S.
Abstract
Objectives: The majority of coronavirus disease 2019 mortality and morbidity is attributable to respiratory failure from severe acute respiratory syndrome coronavirus 2 infection. The pathogenesis underpinning coronavirus disease 2019-induced respiratory failure may be attributable to a dysregulated host immune response. Our objective was to investigate the pathophysiological relationship between proinflammatory cytokines and respiratory failure in severe coronavirus disease 2019. Design: Multicenter prospective observational study. Setting: ICU. Patients: Critically ill patients with coronavirus disease 2019 and noncoronavirus disease 2019 critically ill patients with respiratory failure (ICU control group). Interventions: Daily measurement of serum inflammatory cytokines. Measurements and Main Results: Demographics, comorbidities, clinical, physiologic, and laboratory data were collected daily. Daily serum samples were drawn for measurements of interleukin1β, interleukin-6, interleukin-10, and tumor necrosis factor-α. Pulmonary outcomes were the ratio of Pao₂/Fio₂ and static lung compliance. Twenty-six patients with coronavirus disease 2019 and 22 ICU controls were enrolled. Of the patients with coronavirus disease 2019, 58% developed acute respiratory distress syndrome, 62% required mechanical ventilation, 12% underwent extracorporeal membrane oxygenation, and 23% died. A negative correlation between interleukin-6 and Pao₂/Fio₂ (rho, –0.531; p = 0.0052) and static lung compliance (rho, –0.579; p = 0.033) was found selectively in the coronavirus disease 2019 group. Diagnosis of acute respiratory distress syndrome was associated with significantly elevated serum interleukin-6 and interleukin-1β on the day of diagnosis. Conclusions: The inverse relationship between serum interleukin-6 and Pao₂/Fio₂ and static lung compliance is specific to severe acute respiratory syndrome coronavirus 2 infection in critically ill patients with respiratory failure. Similar observations were not found with interleukin-β or tumor necrosis factor-α.
Item Metadata
Title |
The Association of Inflammatory Cytokines in the Pulmonary Pathophysiology of Respiratory Failure in Critically Ill Patients With Coronavirus Disease 2019
|
Creator |
Stukas, Sophie; Hoiland, Ryan; Cooper, Jennifer; Thiara, Sonny; Griesdale, Donald E.; Thomas, Adam D.; Orde, Matthew M.; English, John C.; Chen, Luke Y. C.; Foster, Denise; Mitra, Anish; Romano, Kali; Sweet, David; Ronco, Juan J.; Kanji, Hussein; Chen, Yu-Wei R.; Wong, Sophia; Wellington, Cheryl L.; Sekhon, Mypinder S.
|
Contributor |
Djavad Mowafaghian Centre for Brain Health; University of British Columbia. Centre for Heart Lung Innovation; International Collaboration on Repair Discoveries; St. Paul's Hospital (Vancouver, B.C.). Division of Critical Care Medicine; University of British Columbia. Division of Hematology. Department of Medicine
|
Publisher |
Wolters Kluwer
|
Date Issued |
2020-09
|
Description |
Objectives: The majority of coronavirus disease 2019 mortality and
morbidity is attributable to respiratory failure from severe acute respiratory syndrome coronavirus 2 infection. The pathogenesis underpinning coronavirus disease 2019-induced respiratory failure may be
attributable to a dysregulated host immune response. Our objective was to investigate the pathophysiological relationship between proinflammatory cytokines and respiratory failure in severe coronavirus
disease 2019.
Design: Multicenter prospective observational study.
Setting: ICU.
Patients: Critically ill patients with coronavirus disease 2019 and
noncoronavirus disease 2019 critically ill patients with respiratory
failure (ICU control group).
Interventions: Daily measurement of serum inflammatory cytokines.
Measurements and Main Results: Demographics, comorbidities,
clinical, physiologic, and laboratory data were collected daily.
Daily serum samples were drawn for measurements of interleukin1β, interleukin-6, interleukin-10, and tumor necrosis factor-α.
Pulmonary outcomes were the ratio of Pao₂/Fio₂ and static lung
compliance. Twenty-six patients with coronavirus disease 2019
and 22 ICU controls were enrolled. Of the patients with coronavirus disease 2019, 58% developed acute respiratory distress
syndrome, 62% required mechanical ventilation, 12% underwent
extracorporeal membrane oxygenation, and 23% died. A negative
correlation between interleukin-6 and Pao₂/Fio₂ (rho, –0.531; p =
0.0052) and static lung compliance (rho, –0.579; p = 0.033) was
found selectively in the coronavirus disease 2019 group. Diagnosis
of acute respiratory distress syndrome was associated with significantly elevated serum interleukin-6 and interleukin-1β on the day
of diagnosis.
Conclusions: The inverse relationship between serum interleukin-6
and Pao₂/Fio₂ and static lung compliance is specific to severe acute
respiratory syndrome coronavirus 2 infection in critically ill patients
with respiratory failure. Similar observations were not found with
interleukin-β or tumor necrosis factor-α.
|
Subject | |
Genre | |
Type | |
Language |
eng
|
Date Available |
2021-06-02
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
DOI |
10.14288/1.0398231
|
URI | |
Affiliation |
Applied Science, Faculty of; Health and Social Development, Faculty of (Okanagan); Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of; Biomedical Engineering, School of; Emergency Medicine, Department of; Health and Exercise Sciences, School of (Okanagan); Medicine, Department of; Pathology and Laboratory Medicine, Department of
|
Citation |
Stukas, S., Hoiland, R. L., Cooper, J., Thiara, S., Griesdale, D. E., Thomas, A. D., Orde, M. M., English, J. C., Chen, L. Y. C., Foster, D., Mitra, A. R., Romano, K., Sweet, D. D., Ronco, J. J., Kanji, H. D., Chen, Y. R., Wong, S. L., Wellington, C. L., & Sekhon, M. S. (2020). The association of inflammatory cytokines in the pulmonary pathophysiology of respiratory failure in critically ill patients with coronavirus disease 2019. Critical Care Explorations, 2(9), e0203-e0203.
|
Publisher DOI |
10.1097/CCE.0000000000000203
|
Peer Review Status |
Reviewed
|
Scholarly Level |
Faculty; Researcher; Postdoctoral; Graduate
|
Copyright Holder |
The Authors
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International