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Enhanced Osteogenic Differentiation of Pluripotent Stem Cells via γ-Secretase Inhibition Helmi, Summer A.; Rohani, Leili; Zaher, Ahmed R.; El Hawary, Youssry M.; Rancourt, Derrick E.
Abstract
Bone healing is a complex, well-organized process. Multiple factors regulate this process, including growth factors, hormones, cytokines, mechanical stimulation, and aging. One of the most important signaling pathways that affect bone healing is the Notch signaling pathway. It has a significant role in controlling the differentiation of bone mesenchymal stem cells and forming new bone. Interventions to enhance the healing of critical-sized bone defects are of great importance, and stem cell transplantations are eminent candidates for treating such defects. Understanding how Notch signaling impacts pluripotent stem cell differentiation can significantly enhance osteogenesis and improve the overall healing process upon transplantation. In Rancourt’s lab, mouse embryonic stem cells (ESC) have been successfully differentiated to the osteogenic cell lineage. This study investigates the role of Notch signaling inhibition in the osteogenic differentiation of mouse embryonic and induced pluripotent stem cells (iPS). Our data showed that Notch inhibition greatly enhanced the differentiation of both mouse embryonic and induced pluripotent stem cells.
Item Metadata
Title |
Enhanced Osteogenic Differentiation of Pluripotent Stem Cells via γ-Secretase Inhibition
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Creator | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2021-05-14
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Description |
Bone healing is a complex, well-organized process. Multiple factors regulate this process, including growth factors, hormones, cytokines, mechanical stimulation, and aging. One of the most important signaling pathways that affect bone healing is the Notch signaling pathway. It has a significant role in controlling the differentiation of bone mesenchymal stem cells and forming new bone. Interventions to enhance the healing of critical-sized bone defects are of great importance, and stem cell transplantations are eminent candidates for treating such defects. Understanding how Notch signaling impacts pluripotent stem cell differentiation can significantly enhance osteogenesis and improve the overall healing process upon transplantation. In Rancourt’s lab, mouse embryonic stem cells (ESC) have been successfully differentiated to the osteogenic cell lineage. This study investigates the role of Notch signaling inhibition in the osteogenic differentiation of mouse embryonic and induced pluripotent stem cells (iPS). Our data showed that Notch inhibition greatly enhanced the differentiation of both mouse embryonic and induced pluripotent stem cells.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2021-05-27
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0398197
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URI | |
Affiliation | |
Citation |
International Journal of Molecular Sciences 22 (10): 5215 (2021)
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Publisher DOI |
10.3390/ijms22105215
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0