UBC Faculty Research and Publications

Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study Williams, Camilla J; Li, Zhixiu; Harvey, Nicholas; Lea, Rodney A; Gurd, Brendon J; Bonafiglia, Jacob T; Papadimitriou, Ioannis; Jacques, Macsue; Croci, Ilaria; Stensvold, Dorthe; Wisloff, Ulrik; Taylor, Jenna L; Gajanand, Trishan; Cox, Emily R; Ramos, Joyce S; Fassett, Robert G; Little, Jonathan P.; Francois, Monique E.; Hearon, Christopher M; Sarma, Satyam; Janssen, Sylvan L J E; Van Craenenbroeck, Emeline M; Beckers, Paul; Cornelissen, Véronique A; Howden, Erin J; Keating, Shelley E; Yan, Xu; Bishop, David J; Bye, Anja; Haupt, Larisa M; Griffiths, Lyn R; Ashton, Kevin J; Brown, Matthew A; Torquati, Luciana; Eynon, Nir; Coombes, Jeff S


Background: Low cardiorespiratory fitness (V̇O₂peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is considerable inter-individual variability in the V̇O₂peak response to the same dose of exercise. Understanding how genetic factors contribute to V̇O₂peak training response may improve personalisation of exercise programs. The aim of this study was to identify genetic variants that are associated with the magnitude of V̇O₂peak response following exercise training. Methods: Participant change in objectively measured V̇O₂peak from 18 different interventions was obtained from a multi-centre study (Predict-HIIT). A genome-wide association study was completed (n = 507), and a polygenic predictor score (PPS) was developed using alleles from single nucleotide polymorphisms (SNPs) significantly associated (P 

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