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Development of Point-of-Care Biosensors for COVID-19 Choi, Jane Ru

Abstract

Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real time polymerase chain reaction (qRT-PCR) have been broadly used to detect COVID-19, they are time-consuming, labor-intensive and are unavailable in remote settings. Point-of-care (POC) biosensors, including chip-based and paper-based biosensors are typically low-cost and user-friendly, which offer tremendous potential for rapid medical diagnosis. This mini review article discusses the recent advances in POC biosensors for COVID-19. First, the development of POC biosensors which are made of polydimethylsiloxane (PDMS), papers, and other flexible materials such as textile, film, and carbon nanosheets are reviewed. The advantages of each biosensors along with the commercially available COVID-19 biosensors are highlighted. Lastly, the existing challenges and future perspectives of developing robust POC biosensors to rapidly identify and manage the spread of COVID-19 are briefly discussed.

Item Metadata

Title
Development of Point-of-Care Biosensors for COVID-19
Creator
Choi, Jane Ru
Contributor
University of British Columbia. Centre for Blood Research; University of British Columbia. Life Sciences Institute
Publisher
Frontiers
Date Issued
2020-05-27
Description
Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real time polymerase chain reaction (qRT-PCR) have been broadly used to detect COVID-19, they are time-consuming, labor-intensive and are unavailable in remote settings. Point-of-care (POC) biosensors, including chip-based and paper-based biosensors are typically low-cost and user-friendly, which offer tremendous potential for rapid medical diagnosis. This mini review article discusses the recent advances in POC biosensors for COVID-19. First, the development of POC biosensors which are made of polydimethylsiloxane (PDMS), papers, and other flexible materials such as textile, film, and carbon nanosheets are reviewed. The advantages of each biosensors along with the commercially available COVID-19 biosensors are highlighted. Lastly, the existing challenges and future perspectives of developing robust POC biosensors to rapidly identify and manage the spread of COVID-19 are briefly discussed.
Subject
POC biosensors; PDMS; paper; flexible materials; COVID-19
Genre
Article
Type
Text
Language
eng
Date Available
2021-04-14
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International
DOI
10.14288/1.0396712
URI
http://hdl.handle.net/2429/77791
Affiliation
Applied Science, Faculty of; Mechanical Engineering, Department of
Citation
Choi JR (2020) Development of Point-of-Care Biosensors for COVID-19. Front. Chem. 8:517.
Publisher DOI
10.3389/fchem.2020.00517
Peer Review Status
Reviewed
Scholarly Level
Postdoctoral
Copyright Holder
Author
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International