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The dynamic morphology of glucose as expressed via Raman and terahertz spectroscopy Fredeen, Naomi V.; Lesack, Nikolai; Ciocoiu, Antonia; Garner, Alexander; Zandberg, Wesley F.; Jirasek, Andrew; Holzman, Jonathan F.

Abstract

The proposed work introduces time-captured Raman and terahertz spectroscopic analyses as orthogonal probes of intramolecular and intermolecular modes in biomolecular structures. The work focuses on glucose given the complexity and dynamics of its anomeric conversion and crystallization. The Raman analyses capture the dynamics of its intramolecular modes – revealing conversion between α and β anomers. At the same time, the terahertz analyses capture the dynamics of its intermolecular modes – showing an evolution from amorphous to crystalline morphology. It is shown that time-captured Raman and terahertz spectroscopy together render a more complete depiction, and deeper understanding, of the biomolecular structure of glucose.

Item Metadata

Title
The dynamic morphology of glucose as expressed via Raman and terahertz spectroscopy
Creator
Fredeen, Naomi V.; Lesack, Nikolai; Ciocoiu, Antonia; Garner, Alexander; Zandberg, Wesley F.; Jirasek, Andrew; Holzman, Jonathan F.
Publisher
OSA Publishing
Date Issued
2020-03-15
Description
The proposed work introduces time-captured Raman and terahertz spectroscopic analyses as orthogonal probes of intramolecular and intermolecular modes in biomolecular structures. The work focuses on glucose given the complexity and dynamics of its anomeric conversion and crystallization. The Raman analyses capture the dynamics of its intramolecular modes – revealing conversion between α and β anomers. At the same time, the terahertz analyses capture the dynamics of its intermolecular modes – showing an evolution from amorphous to crystalline morphology. It is shown that time-captured Raman and terahertz spectroscopy together render a more complete depiction, and deeper understanding, of the biomolecular structure of glucose.
Subject
dynamic morphology of glucose; terahertz spectroscopy
Genre
Article
Type
Text
Language
eng
Date Available
2021-04-08
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0396638
URI
http://hdl.handle.net/2429/77729
Affiliation
Applied Science, Faculty of; Science, Irving K. Barber Faculty of (Okanagan); Chemistry, Department of (Okanagan); Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan); Engineering, School of (Okanagan)
Citation
N. V. Fredeen, N. I. Lesack, A. Ciocoiu, A. M. Garner, W. Zandburg, A. Jirasek, and J. F. Holzman, "The dynamic morphology of glucose as expressed via Raman and terahertz spectroscopy," OSA Continuum, vol. 3, pp. 515-527, 2020.
Publisher DOI
10.1364/OSAC.386119
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
OSA Publishing
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International