UBC Faculty Research and Publications

IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma Shahangian, Kimia; Ngan, David A.; Chen, H. H. Rachel; Oh, Yeni; Tam, Anthony; Wen, Jing; Cheung, Chung; Knight, Darryl A.; Dorscheid, Delbert R.; Hackett, Tillie-Louise; Hughes, Michael R.; McNagny, Kelly M.; Hirota, Jeremy A.; Niikura, Masahiro; Man, S. F. Paul; Sin, Don


Background: Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced increased morbidity from pandemic H1N1 (pH1N1) viral infection and whether blockade of interleukin-4 receptor α (IL-4Rα), a critical mediator of Th2 signalling, improved their outcomes. Methods: Male BALB/c mice were intranasally sensitized with house dust mite antigen (Der p 1) for 2 weeks; the mice were then inoculated intranasally with a single dose of pandemic H1N1 (pH1N1). The mice were administered intraperitoneally anti-IL-4Rα through either a prophylactic or a therapeutic treatment strategy. Results: Infection with pH1N1 of mice sensitized to house dust mite (HDM) led to a 24% loss in weight by day 7 of infection (versus 14% in non-sensitized mice; p 

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