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Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications Gholami, Leila; Nooshabadi, Vajihe T; Shahabi, Shiva; Jazayeri, Marzieh; Tarzemany, Rana; Afsartala, Zohreh; Khorsandi, Khatereh

Abstract

Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.

Item Metadata

Title
Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
Creator
Gholami, Leila; Nooshabadi, Vajihe T; Shahabi, Shiva; Jazayeri, Marzieh; Tarzemany, Rana; Afsartala, Zohreh; Khorsandi, Khatereh
Publisher
BioMed Central
Date Issued
2021-01-12
Description
Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.
Subject
Extracellular vesicles; Mesenchymal stem cells; Bone regeneration; Periodontal regeneration
Genre
Article
Type
Text
Language
eng
Date Available
2021-01-13
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0395582
URI
http://hdl.handle.net/2429/77077
Affiliation
Dentistry, Faculty of; Non UBC; Oral Biological and Medical Sciences (OBMS), Department of
Citation
Cell & Bioscience. 2021 Jan 12;11(1):16
Publisher DOI
10.1186/s13578-020-00527-8
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)