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The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis Shoucair, Issraa; Weber Mello, Fernanda; Jabalee, James; Maleki, Saeideh; Garnis, Cathie
Abstract
Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.
Item Metadata
Title |
The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
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Creator | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2020-09-17
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Description |
Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2020-09-29
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0394557
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URI | |
Affiliation | |
Citation |
International Journal of Molecular Sciences 21 (18): 6837 (2020)
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Publisher DOI |
10.3390/ijms21186837
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0