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Impact of Quadrivalent HPV Vaccine Dose Spacing on Immunologic Response in Women Living with HIV McClymont, Elisabeth; Ogilvie, Gina; Albert, Arianne Y. K.; Johnston, Angela; Raboud, Janet; Walmsley, Sharon; Lipsky, Nancy; Loutfy, Mona; Trottier, Sylvie; Smaill, Fiona; Yudin, Mark H.; Klein, Marina B.; Harris, Marianne; Wendy Wobeser; Bitnun, Ari; Fatima Kakkar; Samson, Lindy; Brophy, Jason; Karatzios, Christos; Money, Deborah M.

Abstract

HPV vaccination schedules have changed as evidence has supported reduced dosing and extended intervals. Women living with HIV (WLWH) represent an important population with no data on alternative dosing. Girls and WLWH received quadrivalent HPV (qHPV) vaccine in a pan-Canadian study of immunogenicity and efficacy. Serology was performed at months 0/2/7/12/18/24. Medical and sexual history was collected throughout. Linear regression was used to determine if spacing of doses was associated with peak antibody titer. Multivariable analyses demonstrated significant relationships between peak antibody titer and time to blood draw post last vaccine dose, naivety to the relevant HPV type, and HIV viral load for all qHPV types. There was a significant relationship between peak HPV16/18 antibody titer and age. Taking age, time to serology, CD4 cell count, CD4 nadir, HIV viral load, and HPV naivety into account, spacing of the three qHPV vaccine doses did not significantly impact peak antibody titers.

Item Metadata

Title
Impact of Quadrivalent HPV Vaccine Dose Spacing on Immunologic Response in Women Living with HIV
Creator
McClymont, Elisabeth; Ogilvie, Gina; Albert, Arianne Y. K.; Johnston, Angela; Raboud, Janet; Walmsley, Sharon; Lipsky, Nancy; Loutfy, Mona; Trottier, Sylvie; Smaill, Fiona; Yudin, Mark H.; Klein, Marina B.; Harris, Marianne; Wendy Wobeser; Bitnun, Ari; Fatima Kakkar; Samson, Lindy; Brophy, Jason; Karatzios, Christos; Money, Deborah M.
Contributor
British Columbia Centre for Excellence in HIV/AIDS; Women's Health Research Institute (British Columbia)
Publisher
Elsevier
Date Issued
2020-03-30
Description
HPV vaccination schedules have changed as evidence has supported reduced dosing and extended intervals. Women living with HIV (WLWH) represent an important population with no data on alternative dosing. Girls and WLWH received quadrivalent HPV (qHPV) vaccine in a pan-Canadian study of immunogenicity and efficacy. Serology was performed at months 0/2/7/12/18/24. Medical and sexual history was collected throughout. Linear regression was used to determine if spacing of doses was associated with peak antibody titer. Multivariable analyses demonstrated significant relationships between peak antibody titer and time to blood draw post last vaccine dose, naivety to the relevant HPV type, and HIV viral load for all qHPV types. There was a significant relationship between peak HPV16/18 antibody titer and age. Taking age, time to serology, CD4 cell count, CD4 nadir, HIV viral load, and HPV naivety into account, spacing of the three qHPV vaccine doses did not significantly impact peak antibody titers.
Subject
HPV vaccine; HIV; HPV; Women
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2021-03-30
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0394375
URI
http://hdl.handle.net/2429/76035
Affiliation
Medicine, Faculty of; Non UBC; Obstetrics and Gynaecology, Department of; Population and Public Health (SPPH), School of
Citation
McClymont E, Ogilvie G, Albert A, et al. Impact of quadrivalent HPV vaccine dose spacing on immunologic response in women living with HIV. Vaccine. 2020;38(15):3073-3078
Publisher DOI
10.1016/j.vaccine.2020.02.075
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International