- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Faculty Research and Publications /
- Prevalent and Persistent Oncogenic HPV Types in a Cohort...
Open Collections
UBC Faculty Research and Publications
Prevalent and Persistent Oncogenic HPV Types in a Cohort of Women Living with HIV Prior to HPV Vaccination McClymont, Elisabeth; Lee, Marette; Raboud, Janet; Coutlée, François; Walmsley, Sharon; Lipsky, Nancy; Loutfy, Mona; Trottier, Sylvie; Smaill, Fiona; Klein, Marina B.; et al.
Abstract
Objective: To describe prevalent and persistent oncogenic HPV types detected in women living with HIV (WLWH) in Canada, including in women with cervical dyskaryosis, and to determine predictors of type-specific HPV persistence. Methods: 252 women were eligible for this sub-analysis of a prospective vaccine immunogenicity cohort study (2 HPV DNA results, ≥1 cervical cytology result pre vaccination). Demographic and clinical data were collected alongside cervical samples for cytology and HPV DNA typing between 2008-2015. Results: Pre-vaccination, HPV16 and HPV52 were the most prevalent oncogenic HPV types. Forty-five percent of participants were infected with ≥1 oncogenic HPV type and one-third of participants had a persistent oncogenic infection. HPV16, 45, and 52 were the most frequently persistent types. Seventeen percent of women had persistent infections with oncogenic HPV types not within currently available vaccines (HPV35/39/51/56/59/68/82). Lower CD4 count significantly predicted HPV persistence (p=0.024). Cervical cytology was 82.9% normal, 2.4% atypical squamous cells of undetermined significance, 11.5% low-grade squamous intraepithelial lesions, and 2.8% high-grade squamous intraepithelial lesions. Conclusion: Unvaccinated WLWH were infected with a wide range of oncogenic HPV types. Our findings highlight the importance of optimal HIV treatment and continued cervical cancer screening as key steps towards global elimination of cervical cancer.
Item Metadata
Title |
Prevalent and Persistent Oncogenic HPV Types in a Cohort of Women Living with HIV Prior to HPV Vaccination
|
Creator | |
Contributor | |
Publisher |
Wiley
|
Date Issued |
2020-04-26
|
Description |
Objective: To describe prevalent and persistent oncogenic HPV types detected in women living with HIV (WLWH) in Canada, including in women with cervical dyskaryosis, and to determine predictors of type-specific HPV persistence.
Methods: 252 women were eligible for this sub-analysis of a prospective vaccine immunogenicity cohort study (2 HPV DNA results, ≥1 cervical cytology result pre
vaccination). Demographic and clinical data were collected alongside cervical samples for cytology and HPV DNA typing between 2008-2015. Results: Pre-vaccination, HPV16 and HPV52 were the most prevalent oncogenic HPV types. Forty-five percent of participants were infected with ≥1 oncogenic HPV type and one-third of participants had a persistent oncogenic infection. HPV16, 45, and 52 were the most frequently persistent types. Seventeen percent of women had persistent infections with oncogenic HPV types not within currently available vaccines (HPV35/39/51/56/59/68/82). Lower CD4 count significantly predicted HPV persistence (p=0.024). Cervical cytology was 82.9% normal, 2.4% atypical squamous cells of undetermined significance, 11.5% low-grade squamous intraepithelial lesions, and 2.8% high-grade squamous intraepithelial lesions. Conclusion: Unvaccinated WLWH were infected with a wide range of oncogenic HPV types. Our findings highlight the importance of optimal HIV treatment and continued cervical cancer screening as key steps towards global elimination of cervical cancer.
|
Subject | |
Geographic Location | |
Genre | |
Type | |
Language |
eng
|
Date Available |
2021-04-26
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
DOI |
10.14288/1.0394374
|
URI | |
Affiliation | |
Citation |
McClymont E, Lee M, Raboud J, et al. Prevalent and persistent oncogenic HPV types in a cohort of women living with HIV prior to HPV vaccination. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics. 2020 Jul;150(1):108-115
|
Publisher DOI |
10.1002/ijgo.13185
|
Peer Review Status |
Reviewed
|
Scholarly Level |
Faculty; Researcher; Graduate
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International