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Design, Engineering and Discovery of Novel α-Helical and β-Boomerang Antimicrobial Peptides against Drug Resistant Bacteria Bhattacharjya, Surajit; Straus, Suzana

Abstract

In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.

Item Metadata

Title
Design, Engineering and Discovery of Novel α-Helical and β-Boomerang Antimicrobial Peptides against Drug Resistant Bacteria
Creator
Bhattacharjya, Surajit; Straus, Suzana
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2020-08-11
Description
In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.
Subject
multi-drug resistant (MDR) bacteria; extensively drug resistant (XDR) bacteria; antimicrobial peptides (AMPs); lipopolysaccharide (LPS) binding; α-helical and β-boomerang AMPs
Genre
Article
Type
Text
Language
eng
Date Available
2020-08-31
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0394094
URI
http://hdl.handle.net/2429/75777
Affiliation
Science, Faculty of; Chemistry, Department of
Citation
International Journal of Molecular Sciences 21 (16): 5773 (2020)
Publisher DOI
10.3390/ijms21165773
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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CC BY 4.0