Open Collections

Ji, Hezhao; Sandstrom, Paul; Paredes, Roger; Harrigan, Paul Richard; Brumme, Chanson J.; Avila Rios, Santiago; Noguera-Julian, Marc; Parkin, Neil; Kantor, Rami

Multidisciplinary Digital Publishing Institute

HIV drug resistance is a major global challenge to successful and sustainable antiretroviral therapy. Next-generation sequencing (NGS)-based HIV drug resistance (HIVDR) assays enable more sensitive and quantitative detection of drug-resistance-associated mutations (DRMs) and outperform Sanger sequencing approaches in detecting lower abundance resistance mutations. While NGS is likely to become the new standard for routine HIVDR testing, many technical and knowledge gaps remain to be resolved before its generalized adoption in regular clinical care, public health, and research. Recognizing this, we conceived and launched an international symposium series on NGS HIVDR, to bring together leading experts in the field to address these issues through in-depth discussions and brainstorming. Following the first symposium in 2018 (Winnipeg, MB Canada, 21–22 February, 2018), a second “Winnipeg Consensus” symposium was held in September 2019 in Winnipeg, Canada, and was focused on external quality assurance strategies for NGS HIVDR assays. In this paper, we summarize this second symposium’s goals and highlights.

Article

eng

Vancouver : University of British Columbia Library

10.14288/1.0392029

Medicine, Faculty of; Other UBC; Non UBC; Medicine, Department of

10.3390/v12060586

Faculty

DSpace