Open Collections

Shrestha, Raunak; Nabavi, Noushin; Volik, Stanislav; Anderson, Shawn; Haegert, Anne; McConeghy, Brian; Sar, Funda; Brahmbhatt, Sonal; Bell, Robert; Le Bihan, Stephane; Wang, Yuzhuo, Ph.D.; Collins, Colin C.; Churg, Andrew

Multidisciplinary Digital Publishing Institute

Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial proliferation that is most commonly encountered as an incidental finding in the peritoneal cavity. There is controversy in the literature about whether WDPM is a neoplasm or a reactive process and, if neoplastic, whether it is a variant or precursor of epithelial malignant mesothelioma or is a different entity. Using whole exome sequencing of five WDPMs of the peritoneum, we have identified distinct mutations in EHD1, ATM, FBXO10, SH2D2A, CDH5, MAGED1, and TP73 shared by WDPM cases but not reported in malignant mesotheliomas. Furthermore, we show that WDPM is strongly enriched with C > A transversion substitution mutations, a pattern that is also not found in malignant mesotheliomas. The WDPMs lacked the alterations involving BAP1, SETD2, NF2, CDKN2A/B, LASTS1/2, PBRM1, and SMARCC1 that are frequently found in malignant mesotheliomas. We conclude that WDPMs are neoplasms that are genetically distinct from malignant mesotheliomas and, based on observed mutations, do not appear to be precursors of malignant mesotheliomas.

Article

eng

Vancouver : University of British Columbia Library

10.14288/1.0392022

Medicine, Faculty of; Other UBC; Non UBC; Urologic Sciences, Department of

10.3390/cancers12061568

Faculty

DSpace