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Connecting the Dots Between Inflammatory Bowel Disease and Metabolic Syndrome: A Focus on Gut-Derived Metabolites Verdugo-Meza, Andrea; Ye, Jiayu; Dadlani, Hansika; Ghosh, Sanjoy; Gibson, Deanna L.

Abstract

The role of the microbiome in health and disease has gained considerable attention and shed light on the etiology of complex diseases like inflammatory bowel disease (IBD) and metabolic syndrome (MetS). Since the microorganisms inhabiting the gut can confer either protective or harmful signals, understanding the functional network between the gut microbes and the host provides a comprehensive picture of health and disease status. In IBD, disruption of the gut barrier enhances microbe infiltration into the submucosae, which enhances the probability that gut-derived metabolites are translocated from the gut to the liver and pancreas. Considering inflammation and the gut microbiome can trigger intestinal barrier dysfunction, risk factors of metabolic diseases such as insulin resistance may have common roots with IBD. In this review, we focus on the overlap between IBD and MetS, and we explore the role of common metabolites in each disease in an attempt to connect a common origin, the gut microbiome and derived metabolites that affect the gut, liver and pancreas.

Item Metadata

Title
Connecting the Dots Between Inflammatory Bowel Disease and Metabolic Syndrome: A Focus on Gut-Derived Metabolites
Creator
Verdugo-Meza, Andrea; Ye, Jiayu; Dadlani, Hansika; Ghosh, Sanjoy; Gibson, Deanna L.
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2020-05-15
Description
The role of the microbiome in health and disease has gained considerable attention and shed light on the etiology of complex diseases like inflammatory bowel disease (IBD) and metabolic syndrome (MetS). Since the microorganisms inhabiting the gut can confer either protective or harmful signals, understanding the functional network between the gut microbes and the host provides a comprehensive picture of health and disease status. In IBD, disruption of the gut barrier enhances microbe infiltration into the submucosae, which enhances the probability that gut-derived metabolites are translocated from the gut to the liver and pancreas. Considering inflammation and the gut microbiome can trigger intestinal barrier dysfunction, risk factors of metabolic diseases such as insulin resistance may have common roots with IBD. In this review, we focus on the overlap between IBD and MetS, and we explore the role of common metabolites in each disease in an attempt to connect a common origin, the gut microbiome and derived metabolites that affect the gut, liver and pancreas.
Subject
immunometabolism; gut microbiome; microbiomics; insulin resistance; metabolism; inflammatory bowel disease
Genre
Article
Type
Text
Language
eng
Date Available
2020-05-28
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0391057
URI
http://hdl.handle.net/2429/74600
Affiliation
Arts and Sciences, Irving K. Barber School of (Okanagan); Medicine, Faculty of; Biology, Department of (Okanagan); Medicine, Department of
Citation
Nutrients 12 (5): 1434 (2020)
Publisher DOI
10.3390/nu12051434
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0