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Trends of Venous Thromboembolism Risk Before and After Diagnosis of Gout : A General Population-Based Study Li, Lingyi; McCormick, Natalie; Sayre, E. C.; Esdaile, John; Lacaille, Diane; Xie, Hui; Choi, Hyon; Aviña-Zubieta, J. Antonio
Abstract
Objective: To estimate the overall risk and the temporal trend of VTE, DVT, and PE before and after gout diagnosis in an incident gout cohort compared with the general population. Methods: We conducted a matched cohort study using a province-wide population-based administrative health database in Canada. We calculated incidence rates (IRs) and multivariable adjusted hazard ratios (HRs) for the risk of VTE, DVT, and PE before and after gout diagnosis. Results: Among 130,708 incident individuals with gout (64% male, mean age 59 years), 2,071 developed VTE, 1,377 developed DVT and 1,012 developed PE. IRs per 1000 person-years for gout were 2.63, 1.74, and 1.28 compared with 2.03, 1.28 and 1.06 for non-gout, respectively. The fully adjusted HRs (95% CI) for VTE, DVT, and PE were 1.22 (1.13-1.32), 1.28 (1.17-1.41), and 1.16 (1.05-1.29). For the pre-gout period, the fully adjusted HRs (95% CI) were 1.51 (1.38-1.64), 1.55 (1.40-1.72) and 1.47 (1.31-1.66) for VTE, DVT, and PE. During the 3rd, 2nd, and 1st years preceding gout, the fully adjusted HRs for VTE were 1.44, 1.56, and 1.62. During the 1st, 2nd, 3rd, 4th, and 5th years after gout, the fully adjusted HRs were 1.63, 1.29, 1.33, 1.28, and 1.22. Similar trends were also seen for DVT and PE. Conclusion: Increased risks of VTE, DVT, and PE were found both before and after gout diagnosis. The risk increased gradually before gout, peaking in the year prior to diagnosis, and then progressively declined. Gout-associated inflammation may contribute to venous thrombosis risk.
Item Metadata
Title |
Trends of Venous Thromboembolism Risk Before and After Diagnosis of Gout : A General Population-Based Study
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Alternate Title |
Risk of VTE before and after gout
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Creator | |
Date Issued |
2019-02-08
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Description |
Objective: To estimate the overall risk and the temporal trend of VTE, DVT, and PE before and after gout diagnosis in an incident gout cohort compared with the general population.
Methods: We conducted a matched cohort study using a province-wide population-based administrative health database in Canada. We calculated incidence rates (IRs) and multivariable adjusted hazard ratios (HRs) for the risk of VTE, DVT, and PE before and after gout diagnosis.
Results: Among 130,708 incident individuals with gout (64% male, mean age 59 years), 2,071 developed VTE, 1,377 developed DVT and 1,012 developed PE. IRs per 1000 person-years for gout were 2.63, 1.74, and 1.28 compared with 2.03, 1.28 and 1.06 for non-gout, respectively. The fully adjusted HRs (95% CI) for VTE, DVT, and PE were 1.22 (1.13-1.32), 1.28 (1.17-1.41), and 1.16 (1.05-1.29). For the pre-gout period, the fully adjusted HRs (95% CI) were 1.51 (1.38-1.64), 1.55 (1.40-1.72) and 1.47 (1.31-1.66) for VTE, DVT, and PE. During the 3rd, 2nd, and 1st years preceding gout, the fully adjusted HRs for VTE were 1.44, 1.56, and 1.62. During the 1st, 2nd, 3rd, 4th, and 5th years after gout, the fully adjusted HRs were 1.63, 1.29, 1.33, 1.28, and 1.22. Similar trends were also seen for DVT and PE.
Conclusion: Increased risks of VTE, DVT, and PE were found both before and after gout diagnosis. The risk increased gradually before gout, peaking in the year prior to diagnosis, and then progressively declined. Gout-associated inflammation may contribute to venous thrombosis risk.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2020-02-08
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0388566
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URI | |
Affiliation | |
Citation |
Aviña-Zubieta JA, Chan J, De Vera MA, Sayre EC, Choi HK, Esdaile JM. The risk of venous thromboembolism in ankylosing spondylitis: a general population-based study. Annals of the Rheumatic Diseases. 2019 Apr;78(4):480-485.
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Publisher DOI |
10.1136/annrheumdis-2018-214388
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty; Researcher
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Rights URI | |
Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International