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Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach Alaghehbandan, Reza; Perez Montiel, Delia; Luis, Ana Silvia; Hes, Ondrej

Abstract

Renal epithelial cell tumors are composed of a heterogeneous group of tumors with variable morphologic, immunohistochemical, and molecular features. A “histo-molecular” approach is now an integral part of defining renal tumors, aiming to be clinically and therapeutically pertinent. Most renal epithelial tumors including the new and emerging entities have distinct molecular and genetic features which can be detected using various methods. Most renal epithelial tumors can be diagnosed easily based on pure histologic findings with or without immunohistochemical examination. Furthermore, molecular-genetic testing can be utilized to assist in arriving at an accurate diagnosis. In this review, we presented the most current knowledge concerning molecular-genetic aspects of renal epithelial neoplasms, which potentially can be used in daily diagnostic practice.

Item Metadata

Title
Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach
Creator
Alaghehbandan, Reza; Perez Montiel, Delia; Luis, Ana Silvia; Hes, Ondrej
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2019-12-30
Description
Renal epithelial cell tumors are composed of a heterogeneous group of tumors with variable morphologic, immunohistochemical, and molecular features. A “histo-molecular” approach is now an integral part of defining renal tumors, aiming to be clinically and therapeutically pertinent. Most renal epithelial tumors including the new and emerging entities have distinct molecular and genetic features which can be detected using various methods. Most renal epithelial tumors can be diagnosed easily based on pure histologic findings with or without immunohistochemical examination. Furthermore, molecular-genetic testing can be utilized to assist in arriving at an accurate diagnosis. In this review, we presented the most current knowledge concerning molecular-genetic aspects of renal epithelial neoplasms, which potentially can be used in daily diagnostic practice.
Subject
kidney; renal cell carcinoma; molecular genetic features; practical approach; review
Genre
Article
Type
Text
Language
eng
Date Available
2020-01-29
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0388479
URI
http://hdl.handle.net/2429/73415
Affiliation
Medicine, Faculty of; Non UBC; Pathology and Laboratory Medicine, Department of
Citation
Cancers 12 (1): 85 (2019)
Publisher DOI
10.3390/cancers12010085
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0