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Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study Yuchi, Weiran; Sbihi, Hind; Davies, Hugh, 1957-; Tamburic, Lillian; Brauer, Michael (Of University of British Columbia)

Abstract

Background: Emerging evidence links road proximity and air pollution with cognitive impairment. Joint effects of noise and greenness have not been evaluated. We investigated associations between road proximity and exposures to air pollution, and joint effects of noise and greenness, on non-Alzheimer’s dementia, Parkinson’s and Alzheimer’s disease and multiple sclerosis within a population-based cohort. Methods: We assembled administrative health database cohorts of 45–84 year old residents (N ~ 678,000) of Metro Vancouver, Canada. Cox proportional hazards models were built to assess associations between exposures and non-Alzheimer’s dementia and Parkinson’s disease. Given reduced case numbers, associations with Alzheimer’s disease and multiple sclerosis were evaluated in nested case-control analyses by conditional logistic regression. Results: Road proximity was associated with all outcomes (e.g. non-Alzheimer’s dementia hazard ratio: 1.14, [95% confidence interval: 1.07–1.20], for living

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Title
Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study
Creator
Yuchi, Weiran; Sbihi, Hind; Davies, Hugh, 1957-; Tamburic, Lillian; Brauer, Michael (Of University of British Columbia)
Publisher
BioMed Central
Date Issued
2020-01-21
Description
Background: Emerging evidence links road proximity and air pollution with cognitive impairment. Joint effects of noise and greenness have not been evaluated. We investigated associations between road proximity and exposures to air pollution, and joint effects of noise and greenness, on non-Alzheimer’s dementia, Parkinson’s and Alzheimer’s disease and multiple sclerosis within a population-based cohort. Methods: We assembled administrative health database cohorts of 45–84 year old residents (N ~ 678,000) of Metro Vancouver, Canada. Cox proportional hazards models were built to assess associations between exposures and non-Alzheimer’s dementia and Parkinson’s disease. Given reduced case numbers, associations with Alzheimer’s disease and multiple sclerosis were evaluated in nested case-control analyses by conditional logistic regression. Results: Road proximity was associated with all outcomes (e.g. non-Alzheimer’s dementia hazard ratio: 1.14, [95% confidence interval: 1.07–1.20], for living
Subject
Road proximity; Air pollution; Greenness; Noise; Neurological disorders; Population-based
Genre
Article
Type
Text
Language
eng
Date Available
2020-01-22
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0388350
URI
http://hdl.handle.net/2429/73370
Affiliation
Medicine, Faculty of; Population and Public Health (SPPH), School of
Citation
Environmental Health. 2020 Jan 21;19(1):8
Publisher DOI
10.1186/s12940-020-0565-4
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Rights

Attribution 4.0 International (CC BY 4.0)