UBC Faculty Research and Publications

Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips : the Johnston County Osteoarthritis Project Sayre, E. C.; Jordan, Joanne M.; Cibere, Jolanda, 1962-; Murphy, Louise; Schwartz, Todd A.; Helmick, Charles G.; Renner, Jordan B.; Rahman, Md Mushfiqur; Aghajanian, Jaafar; Kang, Weiqun; Badley, Elizabeth M.; Kopeć, Jacek A.


Objective To quantify the association of radiographic osteoarthritis in one knee or hip joint with other knee or hip joints. Methods We analyzed baseline data from the Johnston County Osteoarthritis Project (n=3,068). We fit four models for left/right knee/hip. Kellgren Lawrence (KL) radiographic grade severity was based on: KL=0/1 (no/questionable radiographic OA (ROA)); 2 (mild ROA); or 3/4 (moderate/severe ROA). We estimated associations between KL grade in contralateral joints and other joint sites (e.g., worst hip in knee models), adjusting for gender, race/ethnicity (African American/Caucasian), age and measured body mass index, using cumulative odds logistic regression models. Interactions were investigated: race/ethnicity by gender; race/ethnicity and gender by the two explanatory variables. Results Contralateral joint KL grade was strongly associated with KL grade, with odds ratios (ORs) and 95% confidence intervals (CIs) ranging from 9.2 (95% CI=7.1, 11.9) to 225.0 (95% CI=83.6, 605.7). In the left knee model, the contralateral joint association was stronger among African Americans than Caucasians, but for the other models the associations by race/ethnicity were identical. Models examining other joint sites showed weaker but mostly statistically significant associations (ORs from 1.4 to 1.8). Conclusion We find a strong multivariable adjusted association between KL grades in contralateral knees and hips, and a modest association with the other joint site (e.g., knees vs. hips). These results suggest that diagnosis of ROA in one large joint may be a marker for risk of multi-joint ROA, and warrant interventions to reduce the incidence or severity of ROA at these other joints.

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