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Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips : the Johnston County Osteoarthritis Project Sayre, E. C.; Jordan, Joanne M.; Cibere, Jolanda, 1962-; Murphy, Louise; Schwartz, Todd A.; Helmick, Charles G.; Renner, Jordan B.; Rahman, Md Mushfiqur; Aghajanian, Jaafar; Kang, Weiqun; et al.

Abstract

Objective To quantify the association of radiographic osteoarthritis in one knee or hip joint with other knee or hip joints. Methods We analyzed baseline data from the Johnston County Osteoarthritis Project (n=3,068). We fit four models for left/right knee/hip. Kellgren Lawrence (KL) radiographic grade severity was based on: KL=0/1 (no/questionable radiographic OA (ROA)); 2 (mild ROA); or 3/4 (moderate/severe ROA). We estimated associations between KL grade in contralateral joints and other joint sites (e.g., worst hip in knee models), adjusting for gender, race/ethnicity (African American/Caucasian), age and measured body mass index, using cumulative odds logistic regression models. Interactions were investigated: race/ethnicity by gender; race/ethnicity and gender by the two explanatory variables. Results Contralateral joint KL grade was strongly associated with KL grade, with odds ratios (ORs) and 95% confidence intervals (CIs) ranging from 9.2 (95% CI=7.1, 11.9) to 225.0 (95% CI=83.6, 605.7). In the left knee model, the contralateral joint association was stronger among African Americans than Caucasians, but for the other models the associations by race/ethnicity were identical. Models examining other joint sites showed weaker but mostly statistically significant associations (ORs from 1.4 to 1.8). Conclusion We find a strong multivariable adjusted association between KL grades in contralateral knees and hips, and a modest association with the other joint site (e.g., knees vs. hips). These results suggest that diagnosis of ROA in one large joint may be a marker for risk of multi-joint ROA, and warrant interventions to reduce the incidence or severity of ROA at these other joints.

Item Metadata

Title
Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips : the Johnston County Osteoarthritis Project
Alternate Title
Multi-joint associations in radiographic OA
Creator
Sayre, E. C.; Jordan, Joanne M.; Cibere, Jolanda, 1962-; Murphy, Louise; Schwartz, Todd A.; Helmick, Charles G.; Renner, Jordan B.; Rahman, Md Mushfiqur; Aghajanian, Jaafar; Kang, Weiqun; Badley, Elizabeth M.; Kopeć, Jacek A.
Date Issued
2010-04-15
Description
Objective To quantify the association of radiographic osteoarthritis in one knee or hip joint with other knee or hip joints. Methods We analyzed baseline data from the Johnston County Osteoarthritis Project (n=3,068). We fit four models for left/right knee/hip. Kellgren Lawrence (KL) radiographic grade severity was based on: KL=0/1 (no/questionable radiographic OA (ROA)); 2 (mild ROA); or 3/4 (moderate/severe ROA). We estimated associations between KL grade in contralateral joints and other joint sites (e.g., worst hip in knee models), adjusting for gender, race/ethnicity (African American/Caucasian), age and measured body mass index, using cumulative odds logistic regression models. Interactions were investigated: race/ethnicity by gender; race/ethnicity and gender by the two explanatory variables. Results Contralateral joint KL grade was strongly associated with KL grade, with odds ratios (ORs) and 95% confidence intervals (CIs) ranging from 9.2 (95% CI=7.1, 11.9) to 225.0 (95% CI=83.6, 605.7). In the left knee model, the contralateral joint association was stronger among African Americans than Caucasians, but for the other models the associations by race/ethnicity were identical. Models examining other joint sites showed weaker but mostly statistically significant associations (ORs from 1.4 to 1.8). Conclusion We find a strong multivariable adjusted association between KL grades in contralateral knees and hips, and a modest association with the other joint site (e.g., knees vs. hips). These results suggest that diagnosis of ROA in one large joint may be a marker for risk of multi-joint ROA, and warrant interventions to reduce the incidence or severity of ROA at these other joints.
Subject
Polyarthritis; Kellgren lawrence grade; Osteoarthritis; Contralateral; Knee; Hip
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2020-01-10
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0388278
URI
http://hdl.handle.net/2429/73300
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of; Population and Public Health (SPPH), School of
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International