Socioeconomic Status at Diagnosis Influences the Incremental Direct Medical Costs of Systemic Lupus Erythematosus : A Longitudinal Population-Based Study

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Socioeconomic Status at Diagnosis Influences the Incremental Direct Medical Costs of Systemic Lupus Erythematosus : A Longitudinal Population-Based Study McCormick, Natalie; Marra, Carlo A.; Sadatsafavi, Mohsen; Aviña-Zubieta, J. Antonio

Abstract

Objectives To assess the incremental direct medical costs of a population-based cohort of incident systemic lupus erythematosus (SLE) for the first five years after diagnosis, and impact of socioeconomic status (SES) on such incremental costs. Methods From the administrative health databases in British Columbia, Canada, we identified all adults with newly-diagnosed SLE from 1996-2010 and obtained a sample from the general non-SLE population matched on sex, age, and calendar-year. We captured costs for outpatient encounters, hospitalisations, and dispensed medications. Using two-part generalised linear models, we estimated per-person-year incremental costs of SLE (difference in costs between SLE and non-SLE, controlling for covariates) during the first five years after diagnosis, and assessed differences in incremental costs across SES groups. Results We included 4,679 newly-diagnosed SLE (86% identified from hospitalisations or rheumatologists) and 23,219 non-SLE individuals. Per-person direct costs for SLE in the first year after diagnosis averaged $13,038 (2013 Canadian), with 61% from hospitalisations, 23% from outpatient encounters, and 16% from medications; costs for non-SLE averaged $2,431. Following adjustment, incremental costs of SLE during the first five years after diagnosis averaged $10,078 per-person-year (95% CI=$2,062-$32,254). Predicted incremental hospitalisation, outpatient, and medication costs were all significantly-greater for the low-SES patients versus high-SES (additional $1,922 per-person-year in incremental costs for low-SES). Similar patterns were observed when restricting to those followed the full five-years after index date. Conclusion Even in a single-payer, publicly-funded healthcare setting, low SES at SLE diagnosis was associated with significantly-greater direct medical costs for the management of SLE and associated complications.

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Title	Socioeconomic Status at Diagnosis Influences the Incremental Direct Medical Costs of Systemic Lupus Erythematosus : A Longitudinal Population-Based Study
Creator	McCormick, Natalie; Marra, Carlo A.; Sadatsafavi, Mohsen; Aviña-Zubieta, J. Antonio
Date Issued	2019-06-14
Description	Objectives To assess the incremental direct medical costs of a population-based cohort of incident systemic lupus erythematosus (SLE) for the first five years after diagnosis, and impact of socioeconomic status (SES) on such incremental costs. Methods From the administrative health databases in British Columbia, Canada, we identified all adults with newly-diagnosed SLE from 1996-2010 and obtained a sample from the general non-SLE population matched on sex, age, and calendar-year. We captured costs for outpatient encounters, hospitalisations, and dispensed medications. Using two-part generalised linear models, we estimated per-person-year incremental costs of SLE (difference in costs between SLE and non-SLE, controlling for covariates) during the first five years after diagnosis, and assessed differences in incremental costs across SES groups. Results We included 4,679 newly-diagnosed SLE (86% identified from hospitalisations or rheumatologists) and 23,219 non-SLE individuals. Per-person direct costs for SLE in the first year after diagnosis averaged $13,038 (2013 Canadian), with 61% from hospitalisations, 23% from outpatient encounters, and 16% from medications; costs for non-SLE averaged $2,431. Following adjustment, incremental costs of SLE during the first five years after diagnosis averaged $10,078 per-person-year (95% CI=$2,062-$32,254). Predicted incremental hospitalisation, outpatient, and medication costs were all significantly-greater for the low-SES patients versus high-SES (additional $1,922 per-person-year in incremental costs for low-SES). Similar patterns were observed when restricting to those followed the full five-years after index date. Conclusion Even in a single-payer, publicly-funded healthcare setting, low SES at SLE diagnosis was associated with significantly-greater direct medical costs for the management of SLE and associated complications.
Subject	Systemic lupus erythematosus; Health care economics; Socioeconomic health disparity; Socioeconomic status; Disease burden
Genre	Article; Postprint
Type	Text
Language	eng
Date Available	2020-06-14
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0387574
URI	http://hdl.handle.net/2429/73206
Affiliation	Medicine, Faculty of; Pharmaceutical Sciences, Faculty of; Non UBC; Medicine, Department of
Citation	McCormick N, Marra C, Sadatsafavi M, Aviña-Zubieta JA. Socioeconomic Status at Diagnosis Influences the Incremental Direct Medical Costs of Systemic Lupus Erythematosus: A Longitudinal Population-Based Study. Sem Arthritis Rheum. 2019 Jun 14. pii: S0049-0172(18)30146-X.
Publisher DOI	10.1016/j.semarthrit.2019.06.010
Peer Review Status	Reviewed
Scholarly Level	Faculty
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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