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Alterations in resting state networks following in utero SSRI exposure in the neonatal brain Rotem‐Kohavi, Naama; Williams, Lynne J.; Virji‐Babul, Naznin; Bjornson, Bruce H.; Brain, Ursula; Werker, Janet Feldman, 1951-; Grunau, Ruth E.; Miller, Steven P.; Oberlander, Tim F.

Abstract

Background: Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used to treat depression during pregnancy. SSRIs cross the placenta, inhibit serotonin (5HT) reuptake, thereby altering central fetal 5HT signaling. Both prenatal maternal mood disturbances and in utero SSRIs have been associated with altered fetal and infant behavior. Advances in resting-state (rs)fMRI have identified resting-state networks (RSNs) in newborns reflecting functional capacity of auditory and visual networks providing opportunities to examine the impact of early experience on neurodevelopment. We sought to examine the effect of in utero SSRI exposure on neonatal RSN functional organization, accounting for prenatal maternal mood symptoms. We hypothesized that prenatal SSRI-exposure would affect neonatal RSN development independent of prenatal maternal mood disturbances. Methods: Non-exposed (n = 33) and SSRI-exposed (n = 20) 6-day-old neonates underwent (rs)fMRI scan. Clinician-rated, maternal prenatal mood (Hamilton Rating Scales for Depression (HAM-D) and self-report Pregnancy Experiences Scale (PES) were completed during third trimester. Independent component analysis (ICA) was used to extract twenty-two RSNs. Results: SSRI-exposed neonates had higher blood oxygenation level dependent (BOLD) signal in auditory RSN compared with non-exposed neonates, P=0.033 (corrected for multiple comparisons), controlling for maternal mood disturbances and self-reported pregnancy experiences. Conclusions: Increased functional connectivity in auditory RSN in neonates with in utero SSRI exposure, independent of maternal mood disturbances and pregnancy negative experiences, may offer an insight into the functional organization origins of shifts in language perception and altered language development previously reported in infants and children with prenatal SSRI exposure.

Item Metadata

Title
Alterations in resting state networks following in utero SSRI exposure in the neonatal brain
Creator
Rotem‐Kohavi, Naama; Williams, Lynne J.; Virji‐Babul, Naznin; Bjornson, Bruce H.; Brain, Ursula; Werker, Janet Feldman, 1951-; Grunau, Ruth E.; Miller, Steven P.; Oberlander, Tim F.
Contributor
University of British Columbia. Graduate Program in Neuroscience; Children's Hospital (Vancouver, B.C.). Research Institute
Publisher
Elsevier
Date Issued
2018-08-25
Description
Background: Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used to treat depression during pregnancy. SSRIs cross the placenta, inhibit serotonin (5HT) reuptake, thereby altering central fetal 5HT signaling. Both prenatal maternal mood disturbances and in utero SSRIs have been associated with altered fetal and infant behavior. Advances in resting-state (rs)fMRI have identified resting-state networks (RSNs) in newborns reflecting functional capacity of auditory and visual networks providing opportunities to examine the impact of early experience on neurodevelopment. We sought to examine the effect of in utero SSRI exposure on neonatal RSN functional organization, accounting for prenatal maternal mood symptoms. We hypothesized that prenatal SSRI-exposure would affect neonatal RSN development independent of prenatal maternal mood disturbances. Methods: Non-exposed (n = 33) and SSRI-exposed (n = 20) 6-day-old neonates underwent (rs)fMRI scan. Clinician-rated, maternal prenatal mood (Hamilton Rating Scales for Depression (HAM-D) and self-report Pregnancy Experiences Scale (PES) were completed during third trimester. Independent component analysis (ICA) was used to extract twenty-two RSNs. Results: SSRI-exposed neonates had higher blood oxygenation level dependent (BOLD) signal in auditory RSN compared with non-exposed neonates, P=0.033 (corrected for multiple comparisons), controlling for maternal mood disturbances and self-reported pregnancy experiences. Conclusions: Increased functional connectivity in auditory RSN in neonates with in utero SSRI exposure, independent of maternal mood disturbances and pregnancy negative experiences, may offer an insight into the functional organization origins of shifts in language perception and altered language development previously reported in infants and children with prenatal SSRI exposure.
Subject
Resting state networks; Functional MRI; Maternal depression; Neonatal neurodevelopment; Serotonin; Antidepressant drugs
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2019-12-19
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0387227
URI
http://hdl.handle.net/2429/72865
Affiliation
Arts, Faculty of; Medicine, Faculty of; Other UBC; Non UBC; Pediatrics, Department of; Physical Therapy, Department of; Population and Public Health (SPPH), School of; Psychology, Department of
Citation
Rotem-Kohavi, N., Williams, L.J., Virji-Babul, N., Bjornson, B.H., Brain, U., Werker, J.F., Grunau, R.E., Miller, S.P., & Oberlander, T. (2018). Alterations in resting state networks following in utero SSRI exposure in the neonatal brain. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(1), 39-49.
Publisher DOI
10.1016/j.bpsc.2018.08.004
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International