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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates Tomassetti, Mara; Lupidi, Gabriele; Piermattei, Pamela; Rossi, Federico V.; Lillini, Samuele; Bianchini, Gianluca; Aramini, Andrea; Ciufolini, Marco A.; Marcantoni, Enrico
Abstract
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
Item Metadata
Title |
Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates
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Creator | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2019-10-25
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Description |
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2019-11-12
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0385172
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URI | |
Affiliation | |
Citation |
Molecules 24 (21): 3846 (2019)
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Publisher DOI |
10.3390/molecules24213846
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0