Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates Tomassetti, Mara; Lupidi, Gabriele; Piermattei, Pamela; Rossi, Federico V.; Lillini, Samuele; Bianchini, Gianluca; Aramini, Andrea; Ciufolini, Marco A.; Marcantoni, Enrico
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
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