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Use of sildenafil in an infant with persistent pulmonary hypertension secondary to lung and renal hypoplasia – a case report Lavie-Nevo, Karen; Harris, Kevin C; Ting, Joseph Y

Abstract

Background: Premature preterm rupture of membranes (PPROM) is reported to be associated with high rates of neonatal mortality and morbidity. Sildenafil has been used in infants with persistent pulmonary hypertension of newborn (PPHN) due to congenital diaphragmatic hernia (CDH) and bronchopulmonary dysplasia (BPD). Recently, Sildenafil has been evaluated as an alternative or adjunctive pulmonary vasodilator. This case report illustrates the use of early sildenafil for PPHN and right ventricular dysfunction in an unusual setting of lung and renal hypoplasia. Case presentation: A male infant was born at 37 weeks with a birth weight of 2840 g. Rupture of membranes developed at approximately 24 weeks of gestational age (GA). Bilateral small kidneys (

Item Metadata

Title
Use of sildenafil in an infant with persistent pulmonary hypertension secondary to lung and renal hypoplasia – a case report
Creator
Lavie-Nevo, Karen; Harris, Kevin C; Ting, Joseph Y
Publisher
BioMed Central
Date Issued
2019-11-06
Description
Background: Premature preterm rupture of membranes (PPROM) is reported to be associated with high rates of neonatal mortality and morbidity. Sildenafil has been used in infants with persistent pulmonary hypertension of newborn (PPHN) due to congenital diaphragmatic hernia (CDH) and bronchopulmonary dysplasia (BPD). Recently, Sildenafil has been evaluated as an alternative or adjunctive pulmonary vasodilator. This case report illustrates the use of early sildenafil for PPHN and right ventricular dysfunction in an unusual setting of lung and renal hypoplasia. Case presentation: A male infant was born at 37 weeks with a birth weight of 2840 g. Rupture of membranes developed at approximately 24 weeks of gestational age (GA). Bilateral small kidneys (
Subject
Pulmonary hypertension; Sildenafil; Lung hypoplasia; Renal hypoplasia; Targeted neonatal echocardiography
Genre
Article
Type
Text
Language
eng
Date Available
2019-11-06
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0385119
URI
http://hdl.handle.net/2429/72214
Affiliation
Medicine, Faculty of; Non UBC; Pediatrics, Department of
Citation
BMC Pediatrics. 2019 Nov 06;19(1):416
Publisher DOI
10.1186/s12887-019-1801-3
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)

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