UBC Faculty Research and Publications

BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials Sun, Yilan; Milne, Stephen; Jaw, Jen E; Yang, Chen X; Xu, Feng; Li, Xuan; Obeidat, Ma’en; Sin, Don D


Background: There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protective effect – the so-called “obesity paradox”. We aimed to determine the relationship between BMI and the rate of FEV1 decline in data from published clinical trials in COPD. Methods: We performed a systematic review of the literature, and identified 5 randomized controlled trials reporting the association between BMI and FEV₁ decline. Four of these were included in the meta-analyses. We analyzed BMI in 4 categories: BMI-I (

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