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BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials Sun, Yilan; Milne, Stephen; Jaw, Jen E.; Yang, Chen X.; Xu, Feng; Li, Xuan; Obeidat, Ma’en; Sin, Don D.

Abstract

Background: There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protective effect – the so-called “obesity paradox”. We aimed to determine the relationship between BMI and the rate of FEV1 decline in data from published clinical trials in COPD. Methods: We performed a systematic review of the literature, and identified 5 randomized controlled trials reporting the association between BMI and FEV₁ decline. Four of these were included in the meta-analyses. We analyzed BMI in 4 categories: BMI-I (

Item Metadata

Title
BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials
Creator
Sun, Yilan; Milne, Stephen; Jaw, Jen E.; Yang, Chen X.; Xu, Feng; Li, Xuan; Obeidat, Ma’en; Sin, Don D.
Contributor
University of British Columbia. Centre for Heart Lung Innovation; St. Paul's Hospital (Vancouver, B.C.)
Publisher
BioMed Central
Date Issued
2019-10-29
Description
Background: There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protective effect – the so-called “obesity paradox”. We aimed to determine the relationship between BMI and the rate of FEV1 decline in data from published clinical trials in COPD. Methods: We performed a systematic review of the literature, and identified 5 randomized controlled trials reporting the association between BMI and FEV₁ decline. Four of these were included in the meta-analyses. We analyzed BMI in 4 categories: BMI-I (
Genre
Article
Type
Text
Language
eng
Date Available
2019-10-31
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0384835
URI
http://hdl.handle.net/2429/72133
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medicine, Department of; Pathology and Laboratory Medicine, Department of
Citation
Respiratory Research. 2019 Oct 29;20(1):236
Publisher DOI
10.1186/s12931-019-1209-5
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)