Open Collections

UBC Faculty Research and Publications

Dietary Fatty Acids and Host–Microbial Crosstalk in Neonatal Enteric Infection Quin, Candice; Gibson, Deanna L.

Abstract

Human milk is the best nutritional choice for infants. However, in instances where breastfeeding is not possible, infant formulas are used as alternatives. While formula manufacturers attempt to mimic the performance of human breast milk, formula-fed babies consistently have higher incidences of infection from diarrheal diseases than those breastfed. Differences in disease susceptibility, progression and severity can be attributed, in part, to nutritional fatty acid differences between breast milk and formula. Despite advances in our understanding of breast milk properties, formulas still present major differences in their fatty acid composition when compared to human breast milk. In this review, we highlight the role of distinct types of dietary fatty acids in modulating host inflammation, both directly and through the microbiome-immune nexus. We present evidence that dietary fatty acids influence enteric disease susceptibility and therefore, altering the fatty acid composition in formula may be a potential strategy to improve infectious outcomes in formula-fed infants.

Item Metadata

Title
Dietary Fatty Acids and Host–Microbial Crosstalk in Neonatal Enteric Infection
Creator
Quin, Candice; Gibson, Deanna L.
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2019-09-03
Description
Human milk is the best nutritional choice for infants. However, in instances where breastfeeding is not possible, infant formulas are used as alternatives. While formula manufacturers attempt to mimic the performance of human breast milk, formula-fed babies consistently have higher incidences of infection from diarrheal diseases than those breastfed. Differences in disease susceptibility, progression and severity can be attributed, in part, to nutritional fatty acid differences between breast milk and formula. Despite advances in our understanding of breast milk properties, formulas still present major differences in their fatty acid composition when compared to human breast milk. In this review, we highlight the role of distinct types of dietary fatty acids in modulating host inflammation, both directly and through the microbiome-immune nexus. We present evidence that dietary fatty acids influence enteric disease susceptibility and therefore, altering the fatty acid composition in formula may be a potential strategy to improve infectious outcomes in formula-fed infants.
Subject
dietary fatty acids; saturated fatty acids; monounsaturated fatty acids; polyunsaturated fatty acids; formula; enteric infection; infant nutrition
Genre
Article
Type
Text
Language
eng
Date Available
2019-09-23
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0380959
URI
http://hdl.handle.net/2429/71743
Affiliation
Arts and Sciences, Irving K. Barber School of (Okanagan); Medicine, Faculty of; Biology, Department of (Okanagan); Medicine, Department of
Citation
Nutrients 11 (9): 2064 (2019)
Publisher DOI
10.3390/nu11092064
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

CC BY 4.0