Open Collections

UBC Faculty Research and Publications

Adult Premenopausal Bone Health Related to Reproductive Characteristics—Population-Based Data from the Canadian Multicentre Osteoporosis Study (CaMos) Goshtasebi, Azita; Berger, Claudie; Barr, Susan I.; Kovacs, Christopher S.; Towheed, Tanveer; Davison, K. Shawn; Prior, Jerilynn C., 1943-

Abstract

Amenorrhea is important for women’s bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaMos) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures. This study describes the reproductive characteristics of 1532 women aged 30–60 years. BMD relationships with reproductive and other variables were described in the 499 menstruating women. Mean menarche age was 12.8 years, 96% of women were parous and 95% had used combined hormonal contraceptives (CHC). Infertility was reported by 9%, androgen excess by 13%, amenorrhea by 8% and nulliparity by 4%. LS BMD was negatively associated with amenorrhea and androgen excess and positively related to current BMI and height. A later age at menarche negatively related to FN BMD. BMI and height were strongly related to BMD at all sites. Prevalent fragility fractures were significantly associated with quartiles of both LS and TH BMD.

Item Metadata

Title
Adult Premenopausal Bone Health Related to Reproductive Characteristics—Population-Based Data from the Canadian Multicentre Osteoporosis Study (CaMos)
Creator
Goshtasebi, Azita; Berger, Claudie; Barr, Susan I.; Kovacs, Christopher S.; Towheed, Tanveer; Davison, K. Shawn; Prior, Jerilynn C., 1943-
Contributor
Centre for Menstrual Cycle and Ovulation Research (CeMCOR); University of British Columbia. Food, Nutrition and Health Program
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2018-05-18
Description
Amenorrhea is important for women’s bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaMos) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures. This study describes the reproductive characteristics of 1532 women aged 30–60 years. BMD relationships with reproductive and other variables were described in the 499 menstruating women. Mean menarche age was 12.8 years, 96% of women were parous and 95% had used combined hormonal contraceptives (CHC). Infertility was reported by 9%, androgen excess by 13%, amenorrhea by 8% and nulliparity by 4%. LS BMD was negatively associated with amenorrhea and androgen excess and positively related to current BMI and height. A later age at menarche negatively related to FN BMD. BMI and height were strongly related to BMD at all sites. Prevalent fragility fractures were significantly associated with quartiles of both LS and TH BMD.
Subject
Menstrual cycle; Menarche age; Androgen excess; Amenorrhea; Oligomenorrhea; Infertility; Parity; Population-based; Bone mineral density; Prevalent fragility fracture
Genre
Article
Type
Text
Language
eng
Date Available
2019-07-04
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0379752
URI
http://hdl.handle.net/2429/70893
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Endocrinology, Division of; Medicine, Department of; Population and Public Health (SPPH), School of
Citation
International Journal of Environmental Research and Public Health 15 (5): 1023 (2018)
Publisher DOI
10.3390/ijerph15051023
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

CC BY 4.0