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Prevalence of Vitamin D Deficiency Varies Widely by Season in Canadian Children and Adolescents with Sickle Cell Disease Samson, Kaitlyn L. I.; McCartney, Heather; Vercauteren, Suzanne M.; Wu, John K.; Karakochuk, Crystal D.
Abstract
Sickle cell disease (SCD) is an inherited disorder caused by a variant (rs334) in the β-globin gene encoding hemoglobin. Individuals with SCD are thought to be at risk of vitamin D deficiency. Our aim was to assess serum 25-hydroxyvitamin D (25OHD) concentrations, estimate deficiency prevalence, and investigate factors associated with 25OHD concentrations in children and adolescents with SCD attending BC Children’s Hospital in Vancouver, Canada. We conducted a retrospective chart review of SCD patients (2–19 y) from 2012 to 2017. Data were available for n = 45 patients with n = 142 25OHD measurements assessed using a EUROIMMUN analyzer (EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany). Additional data were recorded, including age, sex, and season of blood collection. Linear regression was used to measure associations between 25OHD concentration and predictor variables. Overall, mean ± SD 25OHD concentration was 79 ± 36 nmol/L; prevalence of low 25OHD concentrations (<30, <40, and <75 nmol/L) was 5%, 17% and 50%, respectively. Mean 25OHD concentrations measured during Jul–Sep were higher (28 (95% confidence interval CI: 16–40) nmol/L higher, P < 0.001) compared to Jan–Mar. Vitamin D deficiency rates varied widely by season: Based on 25OHD <30 nmol/L, prevalence was 0% in Oct–Dec and 6% in Jan–Mar; based on <40 nmol/L, prevalence was 0% in Oct–Dec and 26% in Jan–Mar.
Item Metadata
| Title |
Prevalence of Vitamin D Deficiency Varies Widely by Season in Canadian Children and Adolescents with Sickle Cell Disease
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| Creator | |
| Contributor | |
| Publisher |
Multidisciplinary Digital Publishing Institute
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| Date Issued |
2018-01-30
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| Description |
Sickle cell disease (SCD) is an inherited disorder caused by a variant (rs334) in the β-globin
gene encoding hemoglobin. Individuals with SCD are thought to be at risk of vitamin D deficiency.
Our aim was to assess serum 25-hydroxyvitamin D (25OHD) concentrations, estimate deficiency
prevalence, and investigate factors associated with 25OHD concentrations in children and adolescents
with SCD attending BC Children’s Hospital in Vancouver, Canada. We conducted a retrospective
chart review of SCD patients (2–19 y) from 2012 to 2017. Data were available for n = 45 patients with
n = 142 25OHD measurements assessed using a EUROIMMUN analyzer (EUROIMMUN Medizinische
Labordiagnostika AG, Lübeck, Germany). Additional data were recorded, including age, sex, and season
of blood collection. Linear regression was used to measure associations between 25OHD concentration
and predictor variables. Overall, mean ± SD 25OHD concentration was 79 ± 36 nmol/L; prevalence
of low 25OHD concentrations (<30, <40, and <75 nmol/L) was 5%, 17% and 50%, respectively. Mean
25OHD concentrations measured during Jul–Sep were higher (28 (95% confidence interval CI: 16–40)
nmol/L higher, P < 0.001) compared to Jan–Mar. Vitamin D deficiency rates varied widely by season:
Based on 25OHD <30 nmol/L, prevalence was 0% in Oct–Dec and 6% in Jan–Mar; based on <40 nmol/L,
prevalence was 0% in Oct–Dec and 26% in Jan–Mar.
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| Subject | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2019-07-04
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
CC BY 4.0
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| DOI |
10.14288/1.0379748
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| URI | |
| Affiliation | |
| Citation |
Journal of Clinical Medicine 7 (2): 14 (2018)
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| Publisher DOI |
10.3390/jcm7020014
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0