UBC Faculty Research and Publications

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols Weber, Patrick; Nasseri, Seyed A.; Pabst, Bettina M.; Torvisco, Ana; Müller, Philipp; Paschke, Eduard; Tschernutter, Marion; Windischhofer, Werner; Withers, Stephen G.; Wrodnigg, Tanja M.; Stütz, Arnold E.

Abstract

From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and may bear potential as regulators of N-acetyl-d-hexosaminidase activities in vivo.

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