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Bacillamidins A–G from a Marine-Derived Bacillus pumilus Zhou, Si-Yu; Hu, Yi-Jie; Meng, Fan-Cheng; Qu, Shen-Yue; Wang, Rui; Andersen, Raymond J.; Liao, Zhi-Hua; Chen, Min
Abstract
Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.
Item Metadata
Title |
Bacillamidins A–G from a Marine-Derived Bacillus pumilus
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Creator | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2018-09-11
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Description |
Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2019-06-18
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0379483
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URI | |
Affiliation | |
Citation |
Marine Drugs 16 (9): 326 (2018)
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Publisher DOI |
10.3390/md16090326
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0