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Bacillamidins A–G from a Marine-Derived Bacillus pumilus Zhou, Si-Yu; Hu, Yi-Jie; Meng, Fan-Cheng; Qu, Shen-Yue; Wang, Rui; Andersen, Raymond J.; Liao, Zhi-Hua; Chen, Min

Abstract

Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.

Item Metadata

Title
Bacillamidins A–G from a Marine-Derived Bacillus pumilus
Creator
Zhou, Si-Yu; Hu, Yi-Jie; Meng, Fan-Cheng; Qu, Shen-Yue; Wang, Rui; Andersen, Raymond J.; Liao, Zhi-Hua; Chen, Min
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2018-09-11
Description
Seven long-chain amides, including five previously undescribed bacillamidins A–E (1–5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1–4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1–7 were evaluated.
Subject
Bacillus pumilus; Long-chain amides; Cytotoxic activity; Antimicrobial activity
Genre
Article
Type
Text
Language
eng
Date Available
2019-06-18
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0379483
URI
http://hdl.handle.net/2429/70706
Affiliation
Science, Faculty of; Non UBC; Chemistry, Department of
Citation
Marine Drugs 16 (9): 326 (2018)
Publisher DOI
10.3390/md16090326
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0