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Silicon Photonic Biosensors Using Label-Free Detection Luan, Enxiao; Shoman, Hossam; Ratner, Daniel M.; Cheung, Karen C.; Chrostowski, Lukas

Abstract

Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.

Item Metadata

Title
Silicon Photonic Biosensors Using Label-Free Detection
Creator
Luan, Enxiao; Shoman, Hossam; Ratner, Daniel M.; Cheung, Karen C.; Chrostowski, Lukas
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2018-10-18
Description
Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.
Subject
Silicon photonics; Evanescent optical field sensor; Label-free SOI biosensor; Mach–Zehnder interferometer; Ring resonator; Photonic crystal; Bragg grating; Sub-wavelength grating; Lab-on-a-chip; Microfluidics
Genre
Article
Type
Text
Language
eng
Date Available
2019-06-17
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0379463
URI
http://hdl.handle.net/2429/70665
Affiliation
Applied Science, Faculty of; Non UBC; Electrical and Computer Engineering, Department of
Citation
Sensors 18 (10): 3519 (2018)
Publisher DOI
10.3390/s18103519
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0