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Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study Phillips, Aaron A.; Krassioukov, Andrei V.; Zheng, Mei Mu Zi; Warburton, Darren E. R.

Abstract

Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals. Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation). Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs. AB (SBP: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups. Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.

Item Metadata

Title
Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study
Creator
Phillips, Aaron A.; Krassioukov, Andrei V.; Zheng, Mei Mu Zi; Warburton, Darren E. R.
Contributor
University of British Columbia. Physical Activity Promotion and Chronic Disease Prevention Unit; University of British Columbia. Laboratory for Knowledge Mobilization; University of British Columbia. Cardiovascular Physiology and Rehabilitation Laboratory; International Collaboration on Repair Discoveries
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2013-05-08
Description
Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals. Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation). Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs. AB (SBP: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups. Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.
Subject
Spinal cord injury; Neurovascular coupling; Posterior cerebral artery
Genre
Article
Type
Text
Language
eng
Date Available
2019-06-03
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 3.0
DOI
10.14288/1.0379241
URI
http://hdl.handle.net/2429/70482
Affiliation
Medicine, Faculty of; Other UBC; Medicine, Department of
Citation
Brain Sciences 3 (2): 781-789 (2013)
Publisher DOI
10.3390/brainsci3020781
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by-nc-sa/3.0/
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CC BY 3.0