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Offspring Exposure Reduces Depressive-Like Behaviour in the Parturient Female Rat Pawluski, Jodi Lynn; Lieblich, Stephanie E.; Galea, Liisa A. M.
Abstract
In women, breastfeeding generally results in reductions in anxiety and increased positive mood. However, approximately 10–15% of women experience depressed mood and increased anxiety during the first year postpartum. Recent research has demonstrated that offspring-exposure is important for the reduction in behaviours related to depression and anxiety in the mother. It remains to be determined whether these effects are due to factors related to pregnancy and/or pup-exposure, are associated with the degree of maternal behaviour by the mother towards offspring, or persist after weaning. To address these questions the present study used four groups of female rats; primiparous, nulliparous, primip-no-pups (primiparous females with pups permanently removed), and sensitized females. Depressive- and anxiety-like behaviours were assessed one week after weaning/pup-exposure (4 weeks after birth for primip-no-pups animals) using the Forced Swim Test for measures of depressive-like behaviour, and the Open Field Test and Elevated Plus Maze for measure of anxiety-like behaviour. Results demonstrate that primiparous females without pup-exposure have increased depressive-like, but not anxiety-like, behaviour compared to primiparous and sensitized females. In addition, kyphotic nursing by primiparous mothers was negatively related to behavioural measures of depression and anxiety. From this work is it clear that pup-exposure acts is important for reductions in depressive-like behaviour in parturient females. Further research is needed to determine the extent of these changes and the neural and hormonal correlates of these events
Item Metadata
| Title |
Offspring Exposure Reduces Depressive-Like Behaviour in the Parturient Female Rat
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| Creator | |
| Contributor | |
| Date Issued |
2009
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| Description |
In women, breastfeeding generally results in reductions in anxiety and increased
positive mood. However, approximately 10–15% of women experience depressed mood
and increased anxiety during the first year postpartum. Recent research has demonstrated
that offspring-exposure is important for the reduction in behaviours related to depression
and anxiety in the mother. It remains to be determined whether these effects are due to
factors related to pregnancy and/or pup-exposure, are associated with the degree of
maternal behaviour by the mother towards offspring, or persist after weaning. To address
these questions the present study used four groups of female rats; primiparous,
nulliparous, primip-no-pups (primiparous females with pups permanently removed), and
sensitized females. Depressive- and anxiety-like behaviours were assessed one week after
weaning/pup-exposure (4 weeks after birth for primip-no-pups animals) using the Forced
Swim Test for measures of depressive-like behaviour, and the Open Field Test and
Elevated Plus Maze for measure of anxiety-like behaviour. Results demonstrate that
primiparous females without pup-exposure have increased depressive-like, but not
anxiety-like, behaviour compared to primiparous and sensitized females. In addition,
kyphotic nursing by primiparous mothers was negatively related to behavioural measures
of depression and anxiety. From this work is it clear that pup-exposure acts is important
for reductions in depressive-like behaviour in parturient females. Further research is
needed to determine the extent of these changes and the neural and hormonal correlates
of these events
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| Subject | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2019-05-22
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0378932
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| URI | |
| Affiliation | |
| Citation |
Pawluski, J. L., Lieblich, S. E., & Galea, L. A. M. (2009). Offspring-exposure reduces depressive-like behaviour in the parturient female rat. Behavioural Brain Research, 197(1), 55-61.
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| Publisher DOI |
10.1016/j.bbr.2008.08.001
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher; Graduate
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International