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Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis Durrer, Cody; Lewis, Nia; Wan, Zhongxiao; Ainslie, Philip N., 1974-; Jenkins, Nathan T.; Little, Jonathan P.
Abstract
Postprandial hyperglycemia has been linked to elevated risk of cardiovascular disease. Endothelial dysfunction and/or damage may be one of the mechanisms through which this occurs. In this exploratory study, we determined whether acute glucose ingestion would increase markers of endothelial damage/activation and impair endothelial function before and after a short-term low-carbohydrate high-fat diet (HFD) designed to induce relative glucose intolerance. Nine healthy young males (body mass index 23.2 ± 2 kg/m2) consumed a 75 g glucose drink before and <24 hours after consuming seven days of an iso-energetic HFD consisting of ~70% energy from fat, ~10% energy from carbohydrates, and ~20% energy from protein. CD31+/CD42b- and CD62E+ endothelial microparticles (EMPs) were enumerated at fasting, 1 hour (1 h), and 2 hours (2 h) post-consumption of the glucose drink. Flow-mediated dilation (FMD), arterial stiffness, and diameter, velocity, and flow of the common and internal carotid, and vertebral arteries were assessed in the fasting state and 1 h post glucose consumption. After the HFD, CD31+/CD42b- EMPs were elevated at 1 h compared to 2 h (p = 0.037), with a tendency for an increase above fasting (p = 0.06) only post-HFD. CD62E EMPs followed the same pattern with increased concentration at 1 h compared to 2 h (p = 0.005) post-HFD, with a tendency to be increased above fasting levels (p = 0.078). FMD was reduced at 1 h post glucose consumption both pre- (p = 0.01) and post-HFD (p = 0.005). There was also a reduction in FMD in the fasting state following the HFD (p = 0.02). In conclusion, one week of low-carbohydrate high-fat feeding that leads to a relative impairment in glucose homeostasis in healthy young adults may predispose the endothelium to hyperglycemia-induced damage.
Item Metadata
Title |
Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis
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Creator | |
Publisher |
Multidisciplinary Digital Publishing Institute
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Date Issued |
2019-02-26
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Description |
Postprandial hyperglycemia has been linked to elevated risk of cardiovascular disease. Endothelial dysfunction and/or damage may be one of the mechanisms through which this occurs. In this exploratory study, we determined whether acute glucose ingestion would increase markers of endothelial damage/activation and impair endothelial function before and after a short-term low-carbohydrate high-fat diet (HFD) designed to induce relative glucose intolerance. Nine healthy young males (body mass index 23.2 ± 2 kg/m2) consumed a 75 g glucose drink before and <24 hours
after consuming seven days of an iso-energetic HFD consisting of ~70% energy from fat, ~10%
energy from carbohydrates, and ~20% energy from protein. CD31+/CD42b- and CD62E+ endothelial
microparticles (EMPs) were enumerated at fasting, 1 hour (1 h), and 2 hours (2 h) post-consumption of
the glucose drink. Flow-mediated dilation (FMD), arterial stiffness, and diameter, velocity, and flow
of the common and internal carotid, and vertebral arteries were assessed in the fasting state and 1 h
post glucose consumption. After the HFD, CD31+/CD42b- EMPs were elevated at 1 h compared
to 2 h (p = 0.037), with a tendency for an increase above fasting (p = 0.06) only post-HFD. CD62E
EMPs followed the same pattern with increased concentration at 1 h compared to 2 h (p = 0.005)
post-HFD, with a tendency to be increased above fasting levels (p = 0.078). FMD was reduced at 1 h
post glucose consumption both pre- (p = 0.01) and post-HFD (p = 0.005). There was also a reduction in
FMD in the fasting state following the HFD (p = 0.02). In conclusion, one week of low-carbohydrate
high-fat feeding that leads to a relative impairment in glucose homeostasis in healthy young adults
may predispose the endothelium to hyperglycemia-induced damage.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2019-04-23
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Provider |
Vancouver : University of British Columbia Library
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Rights |
CC BY 4.0
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DOI |
10.14288/1.0378351
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URI | |
Affiliation | |
Citation |
Nutrients 11 (3): 489 (2019)
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Publisher DOI |
10.3390/nu11030489
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
CC BY 4.0