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Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame Au, Shelly; Wu, Wei; Panté, Nelly

Abstract

Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus. Electron microscopy evidence suggests that baculoviruses, specifically the Alphabaculoviruses (nucleopolyhedroviruses) and the Betabaculoviruses (granuloviruses), have evolved two very distinct modes for doing this. Here we review historical and current experimental results of baculovirus nuclear import studies, with an emphasis on electron microscopy studies employing the prototypical baculovirus Autographa californica multiple nucleopolyhedrovirus infecting cultured cells. We also discuss the implications of recent studies towards theories of nuclear transport mechanisms.

Item Metadata

Title
Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame
Creator
Au, Shelly; Wu, Wei; Panté, Nelly
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2013-07-23
Description
Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus. Electron microscopy evidence suggests that baculoviruses, specifically the Alphabaculoviruses (nucleopolyhedroviruses) and the Betabaculoviruses (granuloviruses), have evolved two very distinct modes for doing this. Here we review historical and current experimental results of baculovirus nuclear import studies, with an emphasis on electron microscopy studies employing the prototypical baculovirus Autographa californica multiple nucleopolyhedrovirus infecting cultured cells. We also discuss the implications of recent studies towards theories of nuclear transport mechanisms.
Subject
Baculovirus; AcMNPV; Nuclear import; Nuclear pore complex; Viruses
Genre
Article
Type
Text
Language
eng
Date Available
2019-04-15
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 3.0
DOI
10.14288/1.0378222
URI
http://hdl.handle.net/2429/69702
Affiliation
Science, Faculty of; Zoology, Department of
Citation
Viruses 5 (7): 1885-1900 (2013)
Publisher DOI
10.3390/v5071885
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by-nc-sa/3.0/
Aggregated Source Repository
DSpace

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CC BY 3.0