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Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease Martino, David; Ben-Othman, Rym; Harbeson, Danny; Bosco, Anthony

Abstract

Modernization has now been linked to poor developmental experience, the onset of immune dysregulation and rising rates of chronic diseases in many parts of the world. Research across the epidemiological, clinical, and basic science domains supports the concept that poor developmental experience, particularly during prenatal life, can increase the risk of chronic disease, with enduring effects on long-term health. Single ‘omics’ approaches are ill-suited to dealing with the level of complexity that underpins immune dysregulation in early life. A more comprehensive systems-level view is afforded by combining multiple ‘omics’ datasets in order to delineate correlations across multiple resolutions of the genome, and of the genomes of the microorganisms that inhabit us. In this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities afforded by this new domain of medical science.

Item Metadata

Title
Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease
Creator
Martino, David; Ben-Othman, Rym; Harbeson, Danny; Bosco, Anthony
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2019-03-21
Description
Modernization has now been linked to poor developmental experience, the onset of immune dysregulation and rising rates of chronic diseases in many parts of the world. Research across the epidemiological, clinical, and basic science domains supports the concept that poor developmental experience, particularly during prenatal life, can increase the risk of chronic disease, with enduring effects on long-term health. Single ‘omics’ approaches are ill-suited to dealing with the level of complexity that underpins immune dysregulation in early life. A more comprehensive systems-level view is afforded by combining multiple ‘omics’ datasets in order to delineate correlations across multiple resolutions of the genome, and of the genomes of the microorganisms that inhabit us. In this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities afforded by this new domain of medical science.
Subject
Multiomics; Dysregulation; Immune system; Development; Modernity
Genre
Article
Type
Text
Language
eng
Date Available
2019-04-12
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0378172
URI
http://hdl.handle.net/2429/69658
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of; Pediatrics, Department of
Citation
Challenges 10 (1): 23 (2019)
Publisher DOI
10.3390/challe10010023
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0