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Where Do They Come from and Where Do They Go : Candidates for Regulating Extracellular Vesicle Formation in Fungi Oliveira, Débora L.; Rizzo, Juliana; Joffe, Luna S.; Godinho, Rodrigo M. C.; Rodrigues, Marcio L.

Abstract

In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EVs were demonstrated to be immunologically active. Here we review the seminal and most recent findings related to the production of EVs by fungi. Based on the current literature about secretion of fungal molecules and biogenesis of EVs in eukaryotes, we focus our discussion on a list of cellular proteins with the potential to regulate vesicle biogenesis in the fungi.

Item Metadata

Title
Where Do They Come from and Where Do They Go : Candidates for Regulating Extracellular Vesicle Formation in Fungi
Creator
Oliveira, Débora L.; Rizzo, Juliana; Joffe, Luna S.; Godinho, Rodrigo M. C.; Rodrigues, Marcio L.
Contributor
Michael Smith Laboratories
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2013-05-02
Description
In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EVs were demonstrated to be immunologically active. Here we review the seminal and most recent findings related to the production of EVs by fungi. Based on the current literature about secretion of fungal molecules and biogenesis of EVs in eukaryotes, we focus our discussion on a list of cellular proteins with the potential to regulate vesicle biogenesis in the fungi.
Subject
Fungal extracellular vesicles; Extracellular vesicle biogenesis; Exosomes; Flippases; GRASP
Genre
Article
Type
Text
Language
eng
Date Available
2019-04-08
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 3.0
DOI
10.14288/1.0377865
URI
http://hdl.handle.net/2429/69506
Affiliation
Science, Faculty of; Non UBC; Microbiology and Immunology, Department of
Citation
International Journal of Molecular Sciences 14 (5): 9581-9603 (2013)
Publisher DOI
10.3390/ijms14059581
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by-nc-sa/3.0/
Aggregated Source Repository
DSpace

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CC BY 3.0